Cart
sales@molnova.com
ABC99
CAS No. 2331255-53-7
ABC99( ABC-99 | ABC 99 )
Catalog No. M27746 CAS No. 2331255-53-7
ABC99 is a selective irreversible inhibitor of the wnt-deacylating enzyme. ABC99 inhibited NOTUM (IC50: 13 nM). It also showed excellent selectivity across the serine hydrolase family.
Purity : >98% (HPLC)
COA
Datasheet
HNMR
HPLC
MSDS
Handing Instructions
| Size | Price / USD | Stock | Quantity |
| 1 mL x 10 mM in DMSO | 236 | In Stock |
|
| 2MG | 158 | In Stock |
|
| 5MG | 235 | In Stock |
|
| 10MG | 353 | In Stock |
|
| 25MG | 629 | In Stock |
|
| 50MG | 923 | In Stock |
|
| 100MG | 1283 | In Stock |
|
| 200MG | 1730 | In Stock |
|
| 500MG | Get Quote | In Stock |
|
| 1G | Get Quote | In Stock |
|
Biological Information
-
Product NameABC99
-
NoteResearch use only, not for human use.
-
Brief DescriptionABC99 is a selective irreversible inhibitor of the wnt-deacylating enzyme. ABC99 inhibited NOTUM (IC50: 13 nM). It also showed excellent selectivity across the serine hydrolase family.
-
DescriptionABC99 is a selective irreversible inhibitor of the wnt-deacylating enzyme. ABC99 inhibited NOTUM (IC50: 13 nM). It also showed excellent selectivity across the serine hydrolase family.(In Vitro):ABC99 (0.1~10 μΜ; 2 hours; SW620 cells) inhibits NOTUM in a concentration-dependent manner and preserves Wnt-3A activity in the presence of NOTUM in a concentration-dependent manner.
-
In VitroABC99 (0.1~10 μΜ; 2 hours; SW620 cells) inhibits NOTUM in a concentration-dependent manner.ABC99 preserves Wnt-3A activity in the presence of NOTUM in a concentration-dependent manner.Western Blot AnalysisCell Line:SW620 cells Concentration:0.1~10 μΜ Incubation Time:2 hours Result:Inhibited NOTUM in a concentration-dependent manner.
-
In Vivo——
-
SynonymsABC-99 | ABC 99
-
PathwayWnt/Notch/Hedgehog
-
TargetWnt/beta/catenin
-
RecptorTLR4
-
Research Area——
-
Indication——
Chemical Information
-
CAS Number2331255-53-7
-
Formula Weight——
-
Molecular FormulaC22H21ClN4O5
-
Purity>98% (HPLC)
-
SolubilityIn Vitro:?DMSO : 25 mg/mL (54.72 mMul)
-
SMILES——
-
Chemical Name——
Shipping & Storage Information
-
Storage(-20℃)
-
ShippingWith Ice Pack
-
Stability≥ 2 years
Reference
1.Masaki Nakamura, et al. Toll-like receptor 4 signal transduction inhibitor, M62812, suppresses endothelial cell and leukocyte activation and prevents lethal septic shock in mice. Eur.J.Pharmacol. 569 237 PMID:17588563
molnova catalog
related products
-
Pamidronic acid
Pamidronic acid Leads to Bone Necrosis via Suppression of Wnt/β-Catenin Signaling in Human Bone Marrow Mesenchymal Stem Cells.
-
JW74
JW74 antagonizes LiCl-induced activation of the canonical Wnt signaling (IC50: 420 nM).
-
K-756
K-756 is a direct and selective inhibitor of tankyrase (TNKS), which inhibits the ADP-ribosylation activity of TNKS1 (IC50 = 31 nM) and TNKS2 (IC50 = 36 nM).
