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ABC99
CAS No. 2331255-53-7
ABC99( ABC-99 | ABC 99 )
Catalog No. M27746 CAS No. 2331255-53-7
ABC99 is a selective irreversible inhibitor of the wnt-deacylating enzyme. ABC99 inhibited NOTUM (IC50: 13 nM). It also showed excellent selectivity across the serine hydrolase family.
Purity : >98% (HPLC)
COA
Datasheet
HNMR
HPLC
MSDS
Handing Instructions
| Size | Price / USD | Stock | Quantity |
| 1 mL x 10 mM in DMSO | 236 | In Stock |
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| 2MG | 158 | In Stock |
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| 5MG | 235 | In Stock |
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| 10MG | 353 | In Stock |
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| 25MG | 629 | In Stock |
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| 50MG | 923 | In Stock |
|
| 100MG | 1283 | In Stock |
|
| 200MG | 1730 | In Stock |
|
| 500MG | Get Quote | In Stock |
|
| 1G | Get Quote | In Stock |
|
Biological Information
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Product NameABC99
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NoteResearch use only, not for human use.
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Brief DescriptionABC99 is a selective irreversible inhibitor of the wnt-deacylating enzyme. ABC99 inhibited NOTUM (IC50: 13 nM). It also showed excellent selectivity across the serine hydrolase family.
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DescriptionABC99 is a selective irreversible inhibitor of the wnt-deacylating enzyme. ABC99 inhibited NOTUM (IC50: 13 nM). It also showed excellent selectivity across the serine hydrolase family.(In Vitro):ABC99 (0.1~10 μΜ; 2 hours; SW620 cells) inhibits NOTUM in a concentration-dependent manner and preserves Wnt-3A activity in the presence of NOTUM in a concentration-dependent manner.
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In VitroABC99 (0.1~10 μΜ; 2 hours; SW620 cells) inhibits NOTUM in a concentration-dependent manner.ABC99 preserves Wnt-3A activity in the presence of NOTUM in a concentration-dependent manner.Western Blot AnalysisCell Line:SW620 cells Concentration:0.1~10 μΜ Incubation Time:2 hours Result:Inhibited NOTUM in a concentration-dependent manner.
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In Vivo——
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SynonymsABC-99 | ABC 99
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PathwayWnt/Notch/Hedgehog
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TargetWnt/beta/catenin
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RecptorTLR4
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Research Area——
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Indication——
Chemical Information
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CAS Number2331255-53-7
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Formula Weight——
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Molecular FormulaC22H21ClN4O5
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Purity>98% (HPLC)
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SolubilityIn Vitro:?DMSO : 25 mg/mL (54.72 mMul)
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SMILES——
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Chemical Name——
Shipping & Storage Information
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Storage(-20℃)
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ShippingWith Ice Pack
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Stability≥ 2 years
Reference
1.Masaki Nakamura, et al. Toll-like receptor 4 signal transduction inhibitor, M62812, suppresses endothelial cell and leukocyte activation and prevents lethal septic shock in mice. Eur.J.Pharmacol. 569 237 PMID:17588563
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