BML-284 HCL

Research use only, not for human use.

BML-284 HCL is a potent, selective Wnt canonical signaling activator and tubulin polymerization inhibitor.BML-284 HCL does not inhibit the activity of GSK-3β, and may be a useful tool in the study of physiological processes that involve the Wnt pathway.

BML-284 HCL is a potent, selective Wnt canonical signaling activator and tubulin polymerization inhibitor.BML-284 HCL does not inhibit the activity of GSK-3β, and may be a useful tool in the study of physiological processes that involve the Wnt pathway. In a Xenopus model, Wnt agonist 1 (10 μM) mimics the effects of Wnt at the whole-organism level, and affects Xenopus embryonic head specification.

BML-284 (10 μM; 24 hours) induces the expression of β-catenin significantly when compared with the NC group. It also partially reverses the effects induced by pizotifen on E-cadherin and N-cadherin expression in MNK45 and AGS cells compared with the pizotifen-treated group.BML-284 (10 μM; 24 hours) significantly increases the migration and invasion of both MNK45 and AGS cells and partially restores the migratory and invasive abilities of cells inhibited by pizotifen. Western Blot Analysis Cell Line:Human gastric cancer cell lines MNK45 and AGS Concentration:10 μM Incubation Time:24 hours Result:Induced β-catenin expression and reserved E-cadherin and N-cadherin expression in MNK45 and AGS cells.

BML-284 hydrochloride (10 ng) combines with Pyrimethanil (4 mg/L) could partially rescue the malformed phenotype and cardiac defects induced by Pyrimethanil in Tg (myl7:EGFP) transgenic embryos at 5.5 hpf are transferred into plates with 20 embryos.

Wnt agonist 1 HCL

Wnt/Notch/Hedgehog

Wnt/beta/catenin

Wnt

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2095432-75-8

386.84

C19H19ClN4O3

>98% (HPLC)

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NC1=NC(C2=CC=CC(OC)=C2)=CC(NCC3=CC=C(OCO4)C4=C3)=N1.[H]Cl

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(-20℃)

With Ice Pack

≥ 2 years