VU10010( VU 10010 )

Catalog No. M27734 CAS No. 633283-39-3

VU 10010 is allosteric potentiator of M4 acetylcholine receptors.

Purity : >98% (HPLC)

COA

Datasheet

HNMR

HPLC

MSDS

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Biological Information

Product Name

VU10010
Note

Research use only, not for human use.
Brief Description

VU 10010 is allosteric potentiator of M4 acetylcholine receptors.
Description

VU 10010 is allosteric potentiator of M4 acetylcholine receptors.
In Vitro

VU10010 potentiates the M4 response to acetylcholine 47-fold while having no activity at other mAChR subtypes (rM1, rM2, rM3 or rM5). VU10010 causes an increase in affinity for ACh and M4-mediated [35S]GTPγS binding. VU10010 (10 μM) has no agonist, antagonist or allosteric potentiator activity at P2Y1R or mGluR5. The EC50 values are 33 and 0.7 nM for ACh in the absence and presence of VU10010, respectively.
In Vivo

——
Synonyms

VU 10010
Pathway

Cell Cycle/DNA Damage
Target

AChR
Recptor

hCB1
Research Area

——
Indication

——

Chemical Information

CAS Number

633283-39-3
Formula Weight

345.85
Molecular Formula

C17H16ClN3OS
Purity

>98% (HPLC)
Solubility

In Vitro:?DMSO : 125 mg/mL (361.43 mM)
SMILES

Cc1cc(C)c2c(N)c(sc2n1)C(=O)NCc1ccc(Cl)cc1
Chemical Name

——

Shipping & Storage Information

Storage

(-20℃)
Shipping

With Ice Pack
Stability

≥ 2 years

Reference

1.Wang X, et al. Effects of the allosteric antagonist 1-(4-chlorophenyl)-3-[3-(6-pyrrolidin-1-ylpyridin-2-yl)phenyl]urea (PSNCBAM-1) on CB1 receptor modulation in the cerebellum. Mol Pharmacol. 2011 Apr;79(4):758-67.

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