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VU10010
CAS No. 633283-39-3
VU10010( VU 10010 )
Catalog No. M27734 CAS No. 633283-39-3
VU 10010 is allosteric potentiator of M4 acetylcholine receptors.
Purity : >98% (HPLC)
COA
Datasheet
HNMR
HPLC
MSDS
Handing Instructions
| Size | Price / USD | Stock | Quantity |
| 2MG | 29 | In Stock |
|
| 5MG | 46 | In Stock |
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| 10MG | 73 | In Stock |
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| 25MG | 150 | In Stock |
|
| 50MG | 233 | In Stock |
|
| 100MG | 342 | In Stock |
|
| 200MG | 481 | In Stock |
|
| 500MG | Get Quote | In Stock |
|
| 1G | Get Quote | In Stock |
|
Biological Information
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Product NameVU10010
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NoteResearch use only, not for human use.
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Brief DescriptionVU 10010 is allosteric potentiator of M4 acetylcholine receptors.
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DescriptionVU 10010 is allosteric potentiator of M4 acetylcholine receptors.
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In VitroVU10010 potentiates the M4 response to acetylcholine 47-fold while having no activity at other mAChR subtypes (rM1, rM2, rM3 or rM5). VU10010 causes an increase in affinity for ACh and M4-mediated [35S]GTPγS binding. VU10010 (10 μM) has no agonist, antagonist or allosteric potentiator activity at P2Y1R or mGluR5. The EC50 values are 33 and 0.7 nM for ACh in the absence and presence of VU10010, respectively.
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In Vivo——
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SynonymsVU 10010
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PathwayCell Cycle/DNA Damage
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TargetAChR
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RecptorhCB1
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Research Area——
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Indication——
Chemical Information
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CAS Number633283-39-3
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Formula Weight345.85
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Molecular FormulaC17H16ClN3OS
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Purity>98% (HPLC)
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SolubilityIn Vitro:?DMSO : 125 mg/mL (361.43 mM)
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SMILESCc1cc(C)c2c(N)c(sc2n1)C(=O)NCc1ccc(Cl)cc1
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Chemical Name——
Shipping & Storage Information
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Storage(-20℃)
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ShippingWith Ice Pack
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Stability≥ 2 years
Reference
1.Wang X, et al. Effects of the allosteric antagonist 1-(4-chlorophenyl)-3-[3-(6-pyrrolidin-1-ylpyridin-2-yl)phenyl]urea (PSNCBAM-1) on CB1 receptor modulation in the cerebellum. Mol Pharmacol. 2011 Apr;79(4):758-67.
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