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RS 100329
CAS No. 1215654-26-4
RS 100329( RS-100329 )
Catalog No. M27696 CAS No. 1215654-26-4
RS 100329 hydrochloride is an antagonist of α1A-adrenergic receptor.
Purity : >98% (HPLC)
COA
Datasheet
HNMR
HPLC
MSDS
Handing Instructions
| Size | Price / USD | Stock | Quantity |
| 5MG | 55 | In Stock |
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| 10MG | 101 | In Stock |
|
| 25MG | 220 | In Stock |
|
| 50MG | 321 | In Stock |
|
| 100MG | 458 | In Stock |
|
| 200MG | Get Quote | In Stock |
|
| 500MG | Get Quote | In Stock |
|
| 1G | Get Quote | In Stock |
|
Biological Information
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Product NameRS 100329
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NoteResearch use only, not for human use.
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Brief DescriptionRS 100329 hydrochloride is an antagonist of α1A-adrenergic receptor.
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DescriptionRS 100329 hydrochloride is an antagonist of α1A-adrenergic receptor.(In Vitro):In intact CHO-K1 cells expressing human cloned alpha1A-, alpha1B- and alpha1D-AR showed nanomolar affinity and significant alpha1A-AR subtype selectivity for RS 100329 hydrochloride (pKi 9.6: 126 and 50 fold selectivity) over the alpha1B- and alpha1D-AR subtypes respectively. Noradrenaline-induced contractions of human lower urinary tract (LUT) tissues or rabbit bladder neck were competitively antagonized by RS 100329 hydrochloride (pA2 9.2 and 9.2).
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In VitroRS100329 hydrochloride (human lower urinary tract (LUT) tissues) contractions to Norepinephrine (HY-13715) is antagonized in a surmountable and concentration-dependent manner.
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In VivoRS100329 hydrochloride (0.01-0.1 mg/kg; i.v.; Sprague Dawley rats) reduces baseline urethral pressure and inhibit reflex urethral contractions. Animal Model:Sprague Dawley rats (300-390 g) Dosage:0.01-0.1 mg/kg Administration:Intravenous injection Result:Caused a fall in baseline urethral pressure reaching a maximum of 23%.
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SynonymsRS-100329
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PathwayAngiogenesis
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TargetAdrenergic Receptor
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RecptorEGFR|c-Met
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Research Area——
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Indication——
Chemical Information
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CAS Number1215654-26-4
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Formula Weight462.89
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Molecular FormulaC20H26ClF3N4O3
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Purity>98% (HPLC)
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SolubilityIn Vitro:?DMSO : 31.25 mg/mL (67.51 mM)
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SMILESCC(C1=O)=CN=C(O)N1CCCN2CCN(C3=CC=CC=C3OCC(F)(F)F)CC2.Cl
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Chemical Name——
Shipping & Storage Information
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Storage(-20℃)
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ShippingWith Ice Pack
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Stability≥ 2 years
Reference
1.Dokla EME, et al. 1,2,4-Oxadiazole derivatives targeting EGFR and c-Met degradation in TKI resistant NSCLC. Eur J Med Chem. 2019 Aug 9;182:111607.
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