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QX-222 chloride
CAS No. 5369-00-6
QX-222 chloride( QX 222 | Lidocaine N-Methyl Hydrochloride )
Catalog No. M27693 CAS No. 5369-00-6
QX222 is a sodium channel blocker.
Purity : >98% (HPLC)
COA
Datasheet
HNMR
HPLC
MSDS
Handing Instructions
| Size | Price / USD | Stock | Quantity |
| 1 mL x 10 mM in DMSO | 28 | In Stock |
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| 25MG | 49 | In Stock |
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| 50MG | 89 | In Stock |
|
| 100MG | 145 | In Stock |
|
| 200MG | Get Quote | In Stock |
|
| 500MG | Get Quote | In Stock |
|
| 1G | Get Quote | In Stock |
|
Biological Information
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Product NameQX-222 chloride
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NoteResearch use only, not for human use.
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Brief DescriptionQX222 is a sodium channel blocker.
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DescriptionQX222 is a sodium channel blocker.(In Vitro):Compared with μ1-WT (WT, 14.2±1.6% block, n = 8; Y401C, 45.2±3.6% block, n = 9; P < 0.001), μ1 IP-Loop to Heart Sequence (μ1-Y401C) results in a significant block twelve minutes after external application of 500 μM QX222 chloride.(In Vivo):Intravenous infusion administration of 10 mg/kg QX-222 chloride for 7 days reverses spinal nerve ligation (SNL)-induced thermal hypersensitivity and induced antinociception in sham-operated rats.
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In VitroTwelve minutes after external application of 500 μM QX222 chloride, μ1 IP-Loop to Heart Sequence (μ1-Y401C) results in a significant block compared with μ1-WT (WT, 14.2±1.6% block, n = 8; Y401C, 45.2±3.6% block, n = 9; P < 0.001).
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In VivoQX-222 (10 mg/kg; intravenous infusion 7 days) chloride reverses spinal nerve ligation (SNL)-induced thermal hypersensitivity and induced antinociception in sham-operated rats.
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SynonymsQX 222 | Lidocaine N-Methyl Hydrochloride
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PathwayMembrane Transporter/Ion Channel
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TargetSodium Channel
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Recptorc-Src
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Research Area——
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Indication——
Chemical Information
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CAS Number5369-00-6
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Formula Weight220.316
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Molecular FormulaC13H20N2O
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Purity>98% (HPLC)
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SolubilityIn Vitro:?DMSO : 125 mg/mL (486.82 mM)
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SMILESCc1cccc(C)c1\N=C(/[O-])C[N+](C)(C)C
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Chemical Name——
Shipping & Storage Information
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Storage(-20℃)
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ShippingWith Ice Pack
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Stability≥ 2 years
Reference
1.O'Malley DP, et al. Discovery of Pyridazinone and Pyrazolo[1,5-a]pyridine Inhibitors of C-Terminal Src Kinase. ACS Med Chem Lett. 2019 Sep 25;10(10):1486-1491.
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