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Takeda-6d
CAS No. 1125632-93-0
Takeda-6d( —— )
Catalog No. M27581 CAS No. 1125632-93-0
Takeda-6d is a novel, potent DFG-out RAF/vascular endothelial growth factor receptor 2 (VEGFR2) inhibitor with IC50 of 7.0 nM and 2.2 nM, respectively.
Purity : >98% (HPLC)
COA
Datasheet
HNMR
HPLC
MSDS
Handing Instructions
| Size | Price / USD | Stock | Quantity |
| 1 mL x 10 mM in DMSO | 256 | In Stock |
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| 2MG | 130 | In Stock |
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| 5MG | 188 | In Stock |
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| 10MG | 282 | In Stock |
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| 25MG | 463 | In Stock |
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| 50MG | 631 | In Stock |
|
| 100MG | 848 | In Stock |
|
| 200MG | 1135 | In Stock |
|
| 500MG | Get Quote | In Stock |
|
| 1G | Get Quote | In Stock |
|
Biological Information
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Product NameTakeda-6d
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NoteResearch use only, not for human use.
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Brief DescriptionTakeda-6d is a novel, potent DFG-out RAF/vascular endothelial growth factor receptor 2 (VEGFR2) inhibitor with IC50 of 7.0 nM and 2.2 nM, respectively.
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DescriptionTakeda-6d is a novel, potent DFG-out RAF/vascular endothelial growth factor receptor 2 (VEGFR2) inhibitor with IC50 of 7.0 nM and 2.2 nM, respectively.
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In Vitro——
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In VivoTakeda-6D (compound 6d) (10 mg/kg, Orally, once) shows sufficient oral bioavailability (F = 70.5%) in rats.Takeda-6D (0-10 mg/kg, Orally, once) significantly decreases phosphorylation levels of ERK1/24 h after oral administration in an A375 (BRAFV600E mutant) human melanoma xenograft model in rats.Takeda-6D (10 mg/kg, Orally, twice daily for 2 weeks) shows tumor regression with T/Cof ?7.0% without severe toxicity, and this tumor regression should include the efficacy based on the antiangiogenesis potency and BRAF inhibitory activity.
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Synonyms——
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PathwayAngiogenesis
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TargetVEGFR
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Recptor——
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Research Area——
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Indication——
Chemical Information
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CAS Number1125632-93-0
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Formula Weight547.99
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Molecular FormulaC27H19ClFN5O3S
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Purity>98% (HPLC)
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Solubility——
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SMILESN#CC1(CC1)c1cccc(C(Nc(cc(cc2)Oc(cc3)nc4c3nc(NC(C3CC3)=O)s4)c2F)=O)c1Cl
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Chemical Name——
Shipping & Storage Information
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Storage(-20℃)
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ShippingWith Ice Pack
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Stability≥ 2 years
Reference
1.Finn PJ, Sun L, Nampalli S, Xiao H, Nelson JR, Mamone JA, Grossmann G, Flick PK, Fuller CW, Kumar S. Synthesis and application of charge-modified dye-labeled dideoxynucleoside-5'-triphosphates to 'direct-load' DNA sequencing. Nucleic Acids Res. 2002 Jul 1;30(13):2877-85.
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