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ONO-RS-082

CAS No. 99754-06-0

ONO-RS-082( —— )

Catalog No. M27471 CAS No. 99754-06-0

ONO-RS-082 is a Ca2+-independent phospholipase A2 inhibitor.

Purity : >98% (HPLC)

COA Datasheet HNMR HPLC MSDS Handing Instructions
Size Price / USD Stock Quantity
1 mL x 10 mM in DMSO 59 In Stock
2MG 33 In Stock
5MG 53 In Stock
10MG 88 In Stock
25MG 170 In Stock
50MG 276 In Stock
100MG 415 In Stock
200MG 600 In Stock
500MG Get Quote In Stock
1G Get Quote In Stock
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Biological Information

  • Product Name
    ONO-RS-082
  • Note
    Research use only, not for human use.
  • Brief Description
    ONO-RS-082 is a Ca2+-independent phospholipase A2 inhibitor.
  • Description
    ONO-RS-082 is a Ca2+-independent phospholipase A2 inhibitor. (In Vitro):ONO-RS-082 at 3.5 μM was able to inhibit epinephrine-stimulated thromboxane production in human platelets. ONO-RS-082 could also disrupt endosome tubule formation and maintenance of the Golgi complex.
  • In Vitro
    Cell Viability Assay Cell Line:A549 lung epithelial cell lines Concentration:10 μM Incubation Time:2-h pretreatment Result:Completely blocked HXA3-mediated PAO1-induced PMN transepithelial migration. Largely prevented PAO1-induced PGE2 release.
  • In Vivo
    Animal Model:MCT- pulmonary hypertension (PH) rat model Dosage:50 mg/kg/day Administration:Result:Reduced the development of PH in the MCT-PH model for long-term.
  • Synonyms
    ——
  • Pathway
    Others
  • Target
    Other Targets
  • Recptor
    ——
  • Research Area
    ——
  • Indication
    ——

Chemical Information

  • CAS Number
    99754-06-0
  • Formula Weight
    371.86
  • Molecular Formula
    C21H22ClNO3
  • Purity
    >98% (HPLC)
  • Solubility
    In Vitro:?DMSO : 100 mg/mL (268.92 mM)
  • SMILES
    CCCCCc1ccc(\C=C\C(=O)Nc2cc(Cl)ccc2C(O)=O)cc1
  • Chemical Name
    ——

Shipping & Storage Information

  • Storage
    (-20℃)
  • Shipping
    With Ice Pack
  • Stability
    ≥ 2 years

Reference

1.Che L, et al. Feprazone Displays Antiadipogenesis and Antiobesity Capacities in in Vitro 3 T3-L1 Cells and in Vivo Mice. ACS Omega. 2021 Mar 7;6(10):6674-6680.
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