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HNMPA

CAS No. 132541-52-7

HNMPA( —— )

Catalog No. M27459 CAS No. 132541-52-7

HNMPA is an inhibitor of insulin receptor tyrosine kinase and inhibits the serine and tyrosine autophosphorylation of human insulin receptor.

Purity : >98% (HPLC)

COA Datasheet HNMR HPLC MSDS Handing Instructions
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Biological Information

  • Product Name
    HNMPA
  • Note
    Research use only, not for human use.
  • Brief Description
    HNMPA is an inhibitor of insulin receptor tyrosine kinase and inhibits the serine and tyrosine autophosphorylation of human insulin receptor.
  • Description
    HNMPA is an inhibitor of insulin receptor tyrosine kinase and inhibits the serine and tyrosine autophosphorylation of human insulin receptor.(In Vitro):HNMPA reduces neuronal firing after GABA application and blocks GABA-dependent insulin inhibition. HNMPA has no effect on cyclic AMP-dependent protein kinase or protein kinase C activities.
  • In Vitro
    HNMPA inhibits the phosphorylation of a synthetic peptide substrate composed of insulin receptor residues 1290-1319 on serines-1305/1306 by partially purified insulin receptors.HNMPA blocks GABA-dependent insulin inhibition, and reduces neuronal firing after GABA application.
  • In Vivo
    ——
  • Synonyms
    ——
  • Pathway
    Angiogenesis
  • Target
    IGF-1R
  • Recptor
    DNMT3B|Parasite|antimalarial
  • Research Area
    ——
  • Indication
    ——

Chemical Information

  • CAS Number
    132541-52-7
  • Formula Weight
    238.18
  • Molecular Formula
    C11H11O4P
  • Purity
    >98% (HPLC)
  • Solubility
    ——
  • SMILES
    O=P(O)(O)C(O)C=1C=CC=2C=CC=CC2C1
  • Chemical Name
    ——

Shipping & Storage Information

  • Storage
    (-20℃)
  • Shipping
    With Ice Pack
  • Stability
    ≥ 2 years

Reference

1.Tanaka Y, et al.Heme-dependent radical generation: possible involvement in antimalarial action of non-peroxide microbial metabolites, nanaomycin A and radicicol.J Antibiot (Tokyo). 1999 Oct;52(10):880-8.
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