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GSK598809 hydrochloride

CAS No. 863680-44-8

GSK598809 hydrochloride( GSK 598809 | GSK-598809 )

Catalog No. M16254 CAS No. 863680-44-8

GSK598809 hydrochloride is a potent, selective, CNS penetrant and orally bioavailable dopamine D3 receptor antagonist with pKi of 8.9; displays >100-fold selectivity over D2 and H1 receptors.

Purity : >98% (HPLC)

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Biological Information

  • Product Name
    GSK598809 hydrochloride
  • Note
    Research use only, not for human use.
  • Brief Description
    GSK598809 hydrochloride is a potent, selective, CNS penetrant and orally bioavailable dopamine D3 receptor antagonist with pKi of 8.9; displays >100-fold selectivity over D2 and H1 receptors.
  • Description
    GSK598809 hydrochloride is a potent, selective, CNS penetrant and orally bioavailable dopamine D3 receptor antagonist with pKi of 8.9; displays >100-fold selectivity over D2 and H1 receptors; significantly attenuates the expression of conditioned place preference (CPP) to nicotine and cocaine; potentiates the hemodynamic effects of cocaine in dogs, also increases mean arterial blood pressure and heart rate in vivo.Other Indication Phase 2 Clinical.
  • In Vitro
    ——
  • In Vivo
    ——
  • Synonyms
    GSK 598809 | GSK-598809
  • Pathway
    GPCR/G Protein
  • Target
    Dopamine Receptor
  • Recptor
    Dopamine Receptor
  • Research Area
    Other Indications
  • Indication
    Other Disease

Chemical Information

  • CAS Number
    863680-44-8
  • Formula Weight
    517.972
  • Molecular Formula
    C22H24ClF4N5OS
  • Purity
    >98% (HPLC)
  • Solubility
    ——
  • SMILES
    ——
  • Chemical Name
    5-(5-((3-(1-(2-fluoro-4-(trifluoromethyl)phenyl)-3-azabicyclo[3.1.0]hexan-3-yl)propyl)thio)-4-methyl-4H-1,2,4-triazol-3-yl)-4-methyloxazole hydrochloride

Shipping & Storage Information

  • Storage
    (-20℃)
  • Shipping
    With Ice Pack
  • Stability
    ≥ 2 years

Reference

1. Micheli F, et al. J Med Chem. 2010 Jan 14;53(1):374-91. 2. Appel NM, et al. J Pharmacol Exp Ther. 2015 Sep;354(3):484-92. 3. Dodds CM, et al. Appetite. 2012 Aug;59(1):27-33. 4. Searle G, et al. Biol Psychiatry. 2010 Aug 15;68(4):392-9.
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