Imeglimin hydrochloride prevents human endothelial cell death by inhibiting mitochondrial permeability transition without inhibiting mitochondrial respiration.

2-Methylglutaric acid is an organic acid normally found in human urine in healthy adults and children. It is a metabolite of succinic acid a citric acid cycle intermediate.

Etifoxine is an anxiolytic and anticonvulsant drug.?Unlike benzodiazepines, etifoxine appears to produce its anxiolytic effects by binding to β2 and β3 subunits of the GABAA receptor complex, and so is acting at a different target site to benzodiazepines, although the physiological effect that is produced is similar to that of benzodiazepines.