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GBR 12783 dihydrochloride
CAS No. 67469-75-4
GBR 12783 dihydrochloride( GBR12783 2HCl )
Catalog No. M27078 CAS No. 67469-75-4
GBR 12783 dihydrochloride can improve memory performance and increase hippocampal acetylcholine release in rats.
Purity : >98% (HPLC)
COA
Datasheet
HNMR
HPLC
MSDS
Handing Instructions
| Size | Price / USD | Stock | Quantity |
| 1 mL x 10 mM in DMSO | 72 | In Stock |
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| 2MG | 36 | In Stock |
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| 5MG | 57 | In Stock |
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| 10MG | 89 | In Stock |
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| 25MG | 169 | In Stock |
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| 50MG | 249 | In Stock |
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| 100MG | 365 | In Stock |
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| 200MG | Get Quote | In Stock |
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| 500MG | Get Quote | In Stock |
|
| 1G | Get Quote | In Stock |
|
Biological Information
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Product NameGBR 12783 dihydrochloride
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NoteResearch use only, not for human use.
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Brief DescriptionGBR 12783 dihydrochloride can improve memory performance and increase hippocampal acetylcholine release in rats.
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DescriptionGBR 12783 dihydrochloride can improve memory performance and increase hippocampal acetylcholine release in rats.GBR 12783 dihydrochloride is a specific, potent and selective dopamine uptake inhibitor that inhibits the [3H]dopamine uptake by rat and mice striatal synaptosomes with IC50s of 1.8 nM and 1.2 nM, respectively.(In Vivo):GBR 12783 (10 mg/kg; intraperitoneal injection; for 100 minutes; male Sprague-Dawley rats) treatment reinforces specifically dopamine transmission only at synapses instantaneously active, increases hippocampal ACh release and improves memory performance in a passive avoidance task.
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In Vitro——
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In VivoGBR 12783 (10 mg/kg; intraperitoneal injection; for 100 minutes; male Sprague-Dawley rats) treatment reinforces specifically dopamine transmission only at synapses instantaneously active, increases hippocampal ACh release and improves memory performance in a passive avoidance task. Animal Model:Male Sprague-Dawley rats (180-200 g) Dosage:10 mg/kg Administration:Intraperitoneal injection; for 100 minutes Result:For a moderate electric shock intensity (0.4 mA), improveed retention performance, increased hippocampal acetylcholine release in vivo.
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SynonymsGBR12783 2HCl
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PathwayOthers
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TargetOther Targets
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RecptorAMPAR
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Research Area——
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Indication——
Chemical Information
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CAS Number67469-75-4
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Formula Weight485.49
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Molecular FormulaC28H34Cl2N2O
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Purity>98% (HPLC)
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Solubility——
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SMILESCl.Cl.C(CN1CCN(C\C=C\c2ccccc2)CC1)OC(c1ccccc1)c1ccccc1
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Chemical Name——
Shipping & Storage Information
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Storage(-20℃)
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ShippingWith Ice Pack
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Stability≥ 2 years
Reference
1.Jhee SS, Chappell AS, Zarotsky V, et al. Multiple-dose plasma pharmacokinetic and safety study of LY450108 and LY451395 (AMPA receptor potentiators) and their concentration in cerebrospinal fluid in healthy human subjects. J Clin Pharmacol. 2006 Apr;46(4):424-32.
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