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BPK-29 hydrochloride

CAS No. 2444815-73-8

BPK-29 hydrochloride( —— )

Catalog No. M24126 CAS No. 2444815-73-8

BPK-29 hydrochloride is a specific ligand that disrupts the atypical orphan nuclear receptor NR0B1-protein interactions by covalently modifying C274.

Purity : >98% (HPLC)

COA

Datasheet

HNMR

HPLC

MSDS

Handing Instructions

Size	Price / USD	Stock	Quantity
1 mL x 10 mM in DMSO	31	In Stock
5MG	29	In Stock
10MG	51	In Stock
25MG	104	In Stock
50MG	187	In Stock
100MG	269	In Stock
200MG	383	In Stock
500MG	Get Quote	In Stock
1G	Get Quote	In Stock

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Biological Information

Product Name

BPK-29 hydrochloride
Note

Research use only, not for human use.
Brief Description

BPK-29 hydrochloride is a specific ligand that disrupts the atypical orphan nuclear receptor NR0B1-protein interactions by covalently modifying C274.
Description

BPK-29 hydrochloride is a specific ligand that disrupts the atypical orphan nuclear receptor NR0B1-protein interactions by covalently modifying C274. It impairs the anchorage-independent growth of KEAP1-mutant cancer cells.
In Vitro

BPK-29 hydrochloride substantially engages NR0B1 with good overall proteomic selectivity in KEAP1-mutant Non-Small Cell Lung Cancers.
In Vivo

——
Synonyms

——
Pathway

Others
Target

Other Targets
Recptor

Others
Research Area

——
Indication

——

Chemical Information

CAS Number

2444815-73-8
Formula Weight

506.46
Molecular Formula

C26H33Cl2N3O3
Purity

>98% (HPLC)
Solubility

DMSO:62.5 mg/mL (123.41 mM; Need ultrasonic)
SMILES

C1CC(CCN(C1)C(=O)C2=CC=C(C=C2)N3CCOCC3)N(CC4=CC=CC=C4)C(=O)CCl.Cl
Chemical Name

——

Shipping & Storage Information

Storage

(-20℃)
Shipping

With Ice Pack
Stability

≥ 2 years

Reference

1.Bar-Peled L, et al. Chemical Proteomics Identifies Druggable Vulnerabilities in a Genetically Defined Cancer. Cell. 2017 Oct 19;171(3):696-709.e23.

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