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Thalidomide-O-amido-PEG2-C2-NH2 TFA
CAS No. 1957235-75-4
Thalidomide-O-amido-PEG2-C2-NH2 TFA( Cereblon Ligand-Linker Conjugates 10 TFA | E3 Ligase Ligand-Linker Conjugates 24 TFA )
Catalog No. M26947 CAS No. 1957235-75-4
Thalidomide-O-amido-PEG2-C2-NH2 TFA is a synthesized E3 ligase ligand-linker conjugate that incorporates the Thalidomide based cereblon ligand and 2-unit PEG linker used in PROTAC technology.
Purity : >98% (HPLC)
COA
Datasheet
HNMR
HPLC
MSDS
Handing Instructions
| Size | Price / USD | Stock | Quantity |
| 2MG | 28 | In Stock |
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| 5MG | 43 | In Stock |
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| 10MG | 62 | In Stock |
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| 25MG | 105 | In Stock |
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| 50MG | 152 | In Stock |
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| 100MG | 221 | In Stock |
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| 200MG | Get Quote | In Stock |
|
| 500MG | Get Quote | In Stock |
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| 1G | Get Quote | In Stock |
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Biological Information
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Product NameThalidomide-O-amido-PEG2-C2-NH2 TFA
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NoteResearch use only, not for human use.
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Brief DescriptionThalidomide-O-amido-PEG2-C2-NH2 TFA is a synthesized E3 ligase ligand-linker conjugate that incorporates the Thalidomide based cereblon ligand and 2-unit PEG linker used in PROTAC technology.
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DescriptionThalidomide-O-amido-PEG2-C2-NH2 TFA is a synthesized E3 ligase ligand-linker conjugate that incorporates the Thalidomide based cereblon ligand and 2-unit PEG linker used in PROTAC technology.(In Vitro):PROTACs contain two different ligands connected by a linker; one is a ligand for an E3 ubiquitin ligase and the other is for the target protein. PROTACs exploit the intracellular ubiquitin-proteasome system to selectively degrade target proteins.
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In VitroPROTACs contain two different ligands connected by a linker; one is a ligand for an E3 ubiquitin ligase and the other is for the target protein. PROTACs exploit the intracellular ubiquitin-proteasome system to selectively degrade target proteins.
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In Vivo——
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SynonymsCereblon Ligand-Linker Conjugates 10 TFA | E3 Ligase Ligand-Linker Conjugates 24 TFA
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PathwayOthers
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TargetOther Targets
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RecptorH2 receptor
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Research Area——
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Indication——
Chemical Information
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CAS Number1957235-75-4
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Formula Weight576.482
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Molecular FormulaC23H27F3N4O10
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Purity>98% (HPLC)
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SolubilityIn Vitro:? H2O : 150 mg/mL (260.20 mM)
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SMILESOC(=O)C(F)(F)F.NCCOCCOCCNC(=O)COc1cccc2C(=O)N(C3CCC(=O)NC3=O)C(=O)c12
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Chemical Name——
Shipping & Storage Information
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Storage(-20℃)
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ShippingWith Ice Pack
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Stability≥ 2 years
Reference
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Spiroxamine
Spiroxamine is a tertiary amine fungicide and an inhibitor of δ14 reductase and δ8→δ7 isomerase. Spiroxamine inhibits the growth of N. parvum, B. dothidea, D. seriata, and L. theobromae isolates from grape vines.
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MMP-8 Substrate, flu...
MMP-8/MMP-26 Fluorogenic substrate (DNP-Pro-Leu-Ala-Tyr-Trp-Ala-Arg) is a matrix metalloproteinase-8 (MMP-8) fluorogenic substrate. MMP-8/MMP-26 Fluorogenic substrate can be used for the research of atherosclerosis, pulmonary fibrosis, and sepsis.
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Difopein TFA (396834...
Difopein (TFA), a specific and competitive inhibitor of 14-3-3 protein (a highly conserved eukaryotic regulatory molecule), blocking the ability of 14-3-3 to bind to target proteins and inhibits 14-3-3/Ligand interactions. Difopein (TFA) leads to induction of apoptosis and enhances the ability of cisplatin to kill cells.
