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TM-N1324
CAS No. 1144477-35-9
TM-N1324( —— )
Catalog No. M26846 CAS No. 1144477-35-9
TM-N1324 is a GPR39 agonist. TM-N1324 activates human GPR39 with high efficacy and potencies of 280 nM and 9 nM in the absence and presence of Zn2+, respectively.
Purity : >98% (HPLC)
COA
Datasheet
HNMR
HPLC
MSDS
Handing Instructions
| Size | Price / USD | Stock | Quantity |
| 1 mL x 10 mM in DMSO | 93 | In Stock |
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| 2MG | 59 | In Stock |
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| 5MG | 92 | In Stock |
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| 10MG | 180 | In Stock |
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| 25MG | 392 | In Stock |
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| 50MG | 575 | In Stock |
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| 100MG | 817 | In Stock |
|
| 200MG | Get Quote | In Stock |
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| 500MG | Get Quote | In Stock |
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| 1G | Get Quote | In Stock |
|
Biological Information
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Product NameTM-N1324
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NoteResearch use only, not for human use.
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Brief DescriptionTM-N1324 is a GPR39 agonist. TM-N1324 activates human GPR39 with high efficacy and potencies of 280 nM and 9 nM in the absence and presence of Zn2+, respectively.
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DescriptionTM-N1324 is a GPR39 agonist. TM-N1324 activates human GPR39 with high efficacy and potencies of 280 nM and 9 nM in the absence and presence of Zn2+, respectively. TM-N1324 has similar potencies to murine GPR39 with EC50s of 180 nM and 5 nM, respectively.(In Vitro):Measurements of somatostatin confirms that the GPR39 agonist TM-N1324 increases somatostatin release by 53%. TM-N1324 is found to have promising in vitro ADME properties. TM-N1324 has reasonably good aqueous solubility (65 μM at pH 7.0).
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In VitroTM-N1324 activates human GPR39 with high efficacy and potencies of 280 nM and 9 nM in the absence and presence of Zn2+, respectively. TM-N1324 has similar potencies on murine GPR39, 180 nM and 5 nM. TM-N1324 is also found to have promising in vitro ADME properties.TM-N1324 has reasonably good aqueous solubility (65 μM at pH 7.0). Measurements of somatostatin confirms that the GPR39 agonist TM-N1324 increases somatostatin release by 53%.
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In Vivo——
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Synonyms——
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PathwayOthers
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TargetOther Targets
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RecptorBTK
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Research Area——
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Indication——
Chemical Information
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CAS Number1144477-35-9
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Formula Weight397.8
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Molecular FormulaC18H13ClFN7O
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Purity>98% (HPLC)
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SolubilityIn Vitro:?DMSO : 5 mg/mL (12.57 mM)
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SMILESCc1nn(c2N=C(O)CC(c12)c1ccc(F)cc1Cl)-c1ncnc2[nH]cnc12
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Chemical Name——
Shipping & Storage Information
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Storage(-20℃)
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ShippingWith Ice Pack
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Stability≥ 2 years
Reference
1.Valeria Di Battista, et al. Genetics and Pathogenetic Role of Inflammasomes in Philadelphia Negative Chronic Myeloproliferative Neoplasms: A Narrative Review. Int J Mol Sci
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