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TC-N 1752
CAS No. 1211866-85-1
TC-N 1752( —— )
Catalog No. M27722 CAS No. 1211866-85-1
human NaV1.7 channels blocker.
Purity : >98% (HPLC)
COA
Datasheet
HNMR
HPLC
MSDS
Handing Instructions
| Size | Price / USD | Stock | Quantity |
| 1 mL x 10 mM in DMSO | 76 | In Stock |
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| 5MG | 69 | In Stock |
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| 10MG | 113 | In Stock |
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| 25MG | 259 | In Stock |
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| 50MG | 375 | In Stock |
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| 100MG | 533 | In Stock |
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| 200MG | 724 | In Stock |
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| 500MG | Get Quote | In Stock |
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| 1G | Get Quote | In Stock |
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Biological Information
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Product NameTC-N 1752
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NoteResearch use only, not for human use.
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Brief Descriptionhuman NaV1.7 channels blocker.
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Descriptionhuman NaV1.7 channels blocker.(In Vitro):TC-N 1752 exhibits IC50s of 0.2, 0.1, 1.6, 0.5 and 1.4 μM for hNav1.7, hNav1.8, hNav1.9, rNav1.9, and mNav1.9. TC-N 1752 state-dependently inhibits Nav1.7 channel on channels that are 20% inactivated(IC50 = 170 nM) and on fully noninactivated channels(IC50 = 3.6 μM).(In Vivo):TC-N 1752 (5 mg/ml; i.v.) attenuates Freund's adjuvant-induced sensitization of C fiber nociceptors. TC-N 1752 (3-30 mg/kg; orally) exhibits analgesic effects in a dose-dependent manner in a formalin model and reduces thermal hyperalgesia produced by inflammation.
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In VitroTC-N 1752 (compound 52) state-dependently inhibits Nav1.7, with IC50 of 170 nM on channels that are 20% inactivated and IC50 of 3.6 μM on fully noninactivated channels.TC-N 1752 inhibits hNav1.7, hNav1.8, hNav1.9, rNav1.9, and mNav1.9 with IC50s of 0.2, 0.1, 1.6, 0.5 and 1.4 μM, respectively.
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In VivoTC-N 1752 (compound 52) (3-30 mg/kg; p.o.) dose-dependently shows analgesic effect in the Formalin model.TC-N 1752 (3-30 mg/kg; p.o.) decreases thermal hyperalgesia produced by inflammation.TC-N 1752 (5 mg/mL; 500 μL; i.v.) attenuates complete Freund’s adjuvant (CFA)-induced sensitization of C-fiber nociceptors. Animal Model:Rats were injected intraplantar with Formalin Dosage:3, 10, 20, 30 mg/kg Administration: Administered p.o. 120 min prior to Formalin Result:Showed analgesic efficacy starting at the dose of 3 mg/kg, with full efficacy at 20 mg/kg dose.
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Synonyms——
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PathwayOthers
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TargetOther Targets
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Recptor——
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Research Area——
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Indication——
Chemical Information
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CAS Number1211866-85-1
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Formula Weight516.525
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Molecular FormulaC25H27F3N6O3
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Purity>98% (HPLC)
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SolubilityIn Vitro:?DMSO : 125 mg/mL (242.00 mM)
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SMILESC\C(O)=N\c1cccc(\N=c2/ncnc([nH]2)N2CCC(CC2)OCc2ccc(OC(F)(F)F)cc2)c1C
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Chemical Name——
Shipping & Storage Information
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Storage(-20℃)
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ShippingWith Ice Pack
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Stability≥ 2 years
Reference
1.Wang RY, et al. From kinetic-structure analysis to engineering crystalline fiber networks in soft materials. Phys Chem Chem Phys. 2013 Mar 7;15(9):3313-9.
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