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Pyr3
CAS No. 1160514-60-2
Pyr3( —— )
Catalog No. M26800 CAS No. 1160514-60-2
Pyr3 is a selective transient receptor potential canonical channel 3 inhibitor. Pyr3 inhibits TRPC3-mediated Ca2+ influx in a dose-dependent manner(IC50 = 700 nM).
Purity : >98% (HPLC)
COA
Datasheet
HNMR
HPLC
MSDS
Handing Instructions
| Size | Price / USD | Stock | Quantity |
| 2MG | 40 | Get Quote |
|
| 5MG | 63 | Get Quote |
|
| 10MG | 88 | Get Quote |
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| 25MG | 203 | Get Quote |
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| 50MG | 344 | Get Quote |
|
| 100MG | 484 | Get Quote |
|
| 200MG | 699 | Get Quote |
|
| 500MG | 1062 | Get Quote |
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| 1G | Get Quote | Get Quote |
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Biological Information
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Product NamePyr3
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NoteResearch use only, not for human use.
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Brief DescriptionPyr3 is a selective transient receptor potential canonical channel 3 inhibitor. Pyr3 inhibits TRPC3-mediated Ca2+ influx in a dose-dependent manner(IC50 = 700 nM).
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DescriptionPyr3 is a selective transient receptor potential canonical channel 3 inhibitor. Pyr3 inhibits TRPC3-mediated Ca2+ influx in a dose-dependent manner(IC50 = 700 nM).(In Vitro):Pyr3 becomes apparent at 0.3 μM and is almost complete at 3 μM. Ca2+ influx is inhibited by Pyr3 in cells co-expressing TRPC3 plus TRPC6 but not in cells co-expressing TRPC1 plus TRPC5. The Ang II-induced NFAT translocation is suppressed by Pyr3 (IC50 = 0.05 μM), but weakly by Pyr2 (IC50 = 2 μM) in a concentration-dependent manner.
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In VitroPyr3 selectively and directly inhibits TRPC3 channels among TRPC family members. Application of Pyr3 inhibits TRPC3-mediated Ca2+ influx in a dose-dependent manner with the IC50 value of 700 nM. Pyr3 becomes apparent at 0.3 μM, and is almost complete at 3 μM. Interestingly, Ca2+ influx is inhibited by Pyr3 in cells co-expressing TRPC3 plus TRPC6 but not in cells coexpressing TRPC1 plus TRPC5. The Ang II-induced NFAT translocation is suppressed by Pyr3, but weakly by Pyr2 in a concentration-dependent manner (IC50 value was 0.05 μM for Pyr3 and 2 μM for Pyr2).
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In Vivo——
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Synonyms——
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PathwayMembrane Transporter/Ion Channel
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TargetTRP/TRPV Channel
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RecptorLXRα| LXRβ
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Research Area——
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Indication——
Chemical Information
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CAS Number1160514-60-2
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Formula Weight456.63
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Molecular FormulaC16H11Cl3F3N3O3
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Purity>98% (HPLC)
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SolubilityIn Vitro:?DMSO : ≥ 125 mg/mL (273.74 mM)
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SMILESO=C(OCC)C=1C=NN(C2=CC=C(C=C2)NC(=O)C(Cl)=C(Cl)Cl)C1C(F)(F)F
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Chemical Name——
Shipping & Storage Information
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Storage(-20℃)
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ShippingWith Ice Pack
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Stability≥ 2 years
Reference
1.Zuercher WJ, et al. Discovery of tertiary sulfonamides as potent liver X receptor antagonists. J Med Chem. 2010 Apr 22;53(8):3412-6.
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