Pumaprazole

Research use only, not for human use.

Pumaprazole is an antagonist of a reversible proton pump.

Pumaprazole is an antagonist of a reversible proton pump.(In Vivo):Pumaprazole shows identical ID50 values on day 1 (11 μmol/kg, 95% confidence limits of 5 and 23), and on day 7 (10 μmol/kg, 95% confidence limits of 4 and 23) of a repeated dose study in this model. Basal acid secretion in the Ghosh-Schild rat is inhibited by Pumaprazole with a higher efficacy compared to ranitidine. The lower dose of Pumaprazole (27 μmol/kg) rapidly elevates luminal pH up to almost neutrality, the higher dose (54 μmol/kg) further prolongs this pH-elevating effect.

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Pumaprazole is a reversible proton pump antagonist. Basal acid secretion in the Ghosh-Schild rat is inhibited by Pumaprazole with a higher efficacy compare to ranitidine. Pumaprazole displays identical ID50 values on day 1 (11 μmol/kg, 95% confidence limits of 5 and 23) and on day 7 (10 μmol/kg, 95% confidence limits of 4 and 23) of a repeated dose study in this model. The lower dose of Pumaprazole (27 μmol/kg) rapidly elevates luminal pH up to almost neutrality, the higher dose (54 μmol/kg) further prolongs this pH-elevating effect.

BY-841

Membrane Transporter/Ion Channel

Proton Pump

TXNIP-TRX complex

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158364-59-1

338.411

C19H22N4O2

>98% (HPLC)

In Vitro:?DMSO : 100 mg/mL (295.51 mM)

COC(=O)Nc1cccc(C)c1CNc1cccn2c(C)c(C)nc12

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(-20℃)

With Ice Pack

≥ 2 years