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Nesolicaftor

CAS No. 1953130-87-4

Nesolicaftor( PTI-428 | Nesolicaftor )

Catalog No. M26798 CAS No. 1953130-87-4

PTI-428 specifically enhances cystic fibrosis transmembrane conductance regulator protein synthesis.

Purity : >98% (HPLC)

COA Datasheet HNMR HPLC MSDS Handing Instructions
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10MG 357 Get Quote
25MG 617 Get Quote
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Biological Information

  • Product Name
    Nesolicaftor
  • Note
    Research use only, not for human use.
  • Brief Description
    PTI-428 specifically enhances cystic fibrosis transmembrane conductance regulator protein synthesis.
  • Description
    PTI-428 specifically enhances cystic fibrosis transmembrane conductance regulator protein synthesis.
  • In Vitro
    Nesolicaftor (PTI-428) (30 μM, 24 h) can increase CFTR function, such as causing a larger change in inh-172 in 16HBE14o-cells expressing G542X-CFTR, also can increase in F508del-CFTR function of CFBE41o-cells expressing F508del-CFTR in a dose-dependent manner.
  • In Vivo
    ——
  • Synonyms
    PTI-428 | Nesolicaftor
  • Pathway
    Apoptosis
  • Target
    CFTR
  • Recptor
    G-quadruplexe| Telomerase
  • Research Area
    ——
  • Indication
    ——

Chemical Information

  • CAS Number
    1953130-87-4
  • Formula Weight
    354.366
  • Molecular Formula
    C18H18N4O4
  • Purity
    >98% (HPLC)
  • Solubility
    In Vitro:?DMSO : 250 mg/mL (705.50 mM)
  • SMILES
    C[C@@H](O)c1nnc(o1)[C@H]1C[C@@H](C1)NC(=O)c1cc(no1)-c1ccccc1
  • Chemical Name
    ——

Shipping & Storage Information

  • Storage
    (-20℃)
  • Shipping
    With Ice Pack
  • Stability
    ≥ 2 years

Reference

1.Fujimori J, et al. Antitumor effects of telomerase inhibitor TMPyP4 in osteosarcoma cell lines. J Orthop Res. 2011 Nov;29(11):1707-11.
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