N-Boc-PEG5-bromide( —— )

Catalog No. M26767 CAS No. 1392499-32-9

COA

Datasheet

HNMR

HPLC

MSDS

Handing Instructions

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Product Name

N-Boc-PEG5-bromide
Note

Research use only, not for human use.
Brief Description

N-Boc-PEG5-bromide is a cleavable ADC linker used in the synthesis of antibody-drug conjugates (ADCs). N-Boc-PEG5-bromide is a PROTAC linker based on PEG and Alkyl/ether.
Description

N-Boc-PEG5-bromide is a cleavable ADC linker used in the synthesis of antibody-drug conjugates (ADCs). N-Boc-PEG5-bromide is a PROTAC linker based on PEG and Alkyl/ether.(In Vitro):ADCs are comprised of an antibody to which is attached an ADC cytotoxin through an ADC linker. PROTACs contain two different ligands connected by a linker; one is a ligand for an E3 ubiquitin ligase and the other is for the target protein.
In Vitro

PROTACs contain two different ligands connected by a linker; one is a ligand for an E3 ubiquitin ligase and the other is for the target protein. PROTACs exploit the intracellular ubiquitin-proteasome system to selectively degrade target proteins. ADCs are comprised of an antibody to which is attached an ADC cytotoxin through an ADC linker.
In Vivo

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Synonyms

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Pathway

Others
Target

Other Targets
Recptor

ACSS2
Research Area

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Indication

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1.?Dixon, Darryl David, et al. Benzimidazole derivatives as ACSS2 modulators and their preparation. WO2015175845A1

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