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BAY524

CAS No. 1445830-39-6

BAY524( —— )

Catalog No. M22177 CAS No. 1445830-39-6

BAY-524 is an inhibitor of Bub1(IC50 = 450 nM.human Bub1 in the presence of 2 mM ATP).

Purity : >98% (HPLC)

COA Datasheet HNMR HPLC MSDS Handing Instructions
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Biological Information

  • Product Name
    BAY524
  • Note
    Research use only, not for human use.
  • Brief Description
    BAY-524 is an inhibitor of Bub1(IC50 = 450 nM.human Bub1 in the presence of 2 mM ATP).
  • Description
    BAY-524 is an inhibitor of Bub1(IC50 = 450 nM.human Bub1 in the presence of 2 mM ATP).
  • In Vitro
    BAY-524 inhibits the recombinant catalytic domain of human Bub1 with an IC50 of 450 nM.BAY-524 (7-10 μM or 0-30 μM; 14 h or 1 h) specifically inhibit Bub1 kinase.BAY-524 (7 μM , 12 h or 7 μM, 12 μM, 3 h) affects Sgo1 and Sgo2 localization and chromatid cohesion in cells.BAY-524 (7 μM, 10 μM) affects localization and activity of the CPC.BAY-524 (7 μM, 2 h) exerts additive effect on centromere association of CPC.BAY-524 (7 μM, 48 h) marginally affects SAC signaling.BAY-524 (7 μM, 10 μM) sensitizes cells to low doses of paclitaxel. Western Blot Analysis Cell Line:hTERT-RPE1 (RPE1) and HeLa cells Concentration:7-10 μM Incubation Time:14 hResult:Drastically reduced T120 phosphorylation.Immunofluorescence Cell Line:RPE1 and HeLa cells Concentration:0-30 μM Incubation Time:1 hResult:Reduced histone H2A-T120 phosphorylation.
  • In Vivo
    ——
  • Synonyms
    ——
  • Pathway
    Others
  • Target
    Other Targets
  • Recptor
    Bub1
  • Research Area
    ——
  • Indication
    ——

Chemical Information

  • CAS Number
    1445830-39-6
  • Formula Weight
    482.48
  • Molecular Formula
    C24H24F2N6O3
  • Purity
    >98% (HPLC)
  • Solubility
    DMSO:150 mg/mL?(310.89 mM;?Need ultrasonic)
  • SMILES
    CCOc1cc(F)c(Cn2nc(c(C)c2OC)-c2ncc(OC)c(Nc3ccncc3)n2)c(F)c1
  • Chemical Name
    ——

Shipping & Storage Information

  • Storage
    (-20℃)
  • Shipping
    With Ice Pack
  • Stability
    ≥ 2 years

Reference

1.Baron AP, et al. Probing the catalytic functions of Bub1 kinase using the small molecule inhibitors BAY-320 and BAY-524. Elife. 2016 Feb 17;5. pii: e12187.
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