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GT 949
CAS No. 460330-27-2
GT 949( —— )
Catalog No. M26706 CAS No. 460330-27-2
GT 949 is a selective excitatory positive allosteric modulator of amino acid transporter-2 (EAAT2) (EC50: 0.26 nM).
Purity : >98% (HPLC)
COA
Datasheet
HNMR
HPLC
MSDS
Handing Instructions
| Size | Price / USD | Stock | Quantity |
| 1 mL x 10 mM in DMSO | 29 | In Stock |
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| 10MG | 46 | In Stock |
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| 25MG | 91 | In Stock |
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| 50MG | 161 | In Stock |
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| 100MG | 242 | In Stock |
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| 200MG | 343 | In Stock |
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| 500MG | Get Quote | In Stock |
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| 1G | Get Quote | In Stock |
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Biological Information
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Product NameGT 949
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NoteResearch use only, not for human use.
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Brief DescriptionGT 949 is a selective excitatory positive allosteric modulator of amino acid transporter-2 (EAAT2) (EC50: 0.26 nM).
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DescriptionGT 949 is a selective excitatory positive allosteric modulator of amino acid transporter-2 (EAAT2) (EC50: 0.26 nM).(In Vitro):GT 949 displays selectivity to EAAT2 and has no effect on glutamate activity mediated by EAAT1 or EAAT3. GT 949 improves glutamate transport (EC50 = 0.26 nM) and increases glutamate transport in a non-competitive manner with an increase in Vmax of about 47% in EAAT2-transfected cells.
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In VitroGT 949 (GT949) enhances glutamate transport with an EC50 of 0.26 ± 0.03 nM. GT 949 also demonstrates selectivity to EAAT2 and has no effect on glutamate activity mediated by EAAT1 or EAAT3.GT 949 is also tested for its effect on glutamate uptake kinetics in EAAT2-transfected cells. GT 949 enhances glutamate transport in a noncompetitive fashion, with increase in Vmax of about 47%.
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In Vivo——
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Synonyms——
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PathwayOthers
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TargetOther Targets
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Recptor5-HT| Dopamine
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Research Area——
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Indication——
Chemical Information
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CAS Number460330-27-2
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Formula Weight527.673
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Molecular FormulaC30H37N7O2
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Purity>98% (HPLC)
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SolubilityIn Vitro:?DMSO : 50 mg/mL (94.76 mM)
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SMILESCOc1ccc2[nH]c(=O)c(cc2c1)C(N1CCN(CC1)C1CCCCC1)c1nnnn1CCc1ccccc1
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Chemical Name——
Shipping & Storage Information
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Storage(-20℃)
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ShippingWith Ice Pack
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Stability≥ 2 years
Reference
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3,5-Di-O-caffeoylqui...
3,5-Di-O-caffeoylquinic acid methyl ester exhibits potent inhibitory activities against the formation of advanced glycation end products (AGEs); it exhibits cytotoxicity actions against human cervix carcinoma HeLa cells. 3,5-Di-O-caffeoylquinic acid methyl ester shows high efficiency and low toxicity with antivirus activity against RSV.
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Picroside II
Picroside II is extracted from Picrorhiza.
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OD1
Potent rat Nav1.7, human Nav1.4 and rat Nav1.6 channel activator (EC50 values are 7, 10 and 47 nM, respectively). Exhibits minimal activation at mammalian Nav1.2, Nav1.3 and Nav1.5 (EC50 values >3 μM). Inhibits fast inactivation on all channels. Increases peak currents at all voltages and stimulates a persistent Na+ current at hNav1.7 channel. Increases hyperpolarization at Nav1.4 and Nav1.6 channels. Induces spontaneous pain in vivo.
