GT 949( —— )

Catalog No. M26706 CAS No. 460330-27-2

GT 949 is a selective excitatory positive allosteric modulator of amino acid transporter-2 (EAAT2) (EC50: 0.26 nM).

Purity : >98% (HPLC)

COA

Datasheet

HNMR

HPLC

MSDS

Handing Instructions

Size	Price / USD	Stock	Quantity
1 mL x 10 mM in DMSO	29	In Stock
10MG	46	In Stock
25MG	91	In Stock
50MG	161	In Stock
100MG	242	In Stock
200MG	343	In Stock
500MG	Get Quote	In Stock
1G	Get Quote	In Stock

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Biological Information

Product Name

GT 949
Note

Research use only, not for human use.
Brief Description

GT 949 is a selective excitatory positive allosteric modulator of amino acid transporter-2 (EAAT2) (EC50: 0.26 nM).
Description

GT 949 is a selective excitatory positive allosteric modulator of amino acid transporter-2 (EAAT2) (EC50: 0.26 nM).(In Vitro):GT 949 displays selectivity to EAAT2 and has no effect on glutamate activity mediated by EAAT1 or EAAT3. GT 949 improves glutamate transport (EC50 = 0.26 nM) and increases glutamate transport in a non-competitive manner with an increase in Vmax of about 47% in EAAT2-transfected cells.
In Vitro

GT 949 (GT949) enhances glutamate transport with an EC50 of 0.26 ± 0.03 nM. GT 949 also demonstrates selectivity to EAAT2 and has no effect on glutamate activity mediated by EAAT1 or EAAT3.GT 949 is also tested for its effect on glutamate uptake kinetics in EAAT2-transfected cells. GT 949 enhances glutamate transport in a noncompetitive fashion, with increase in Vmax of about 47%.
In Vivo

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Synonyms

——
Pathway

Others
Target

Other Targets
Recptor

5-HT| Dopamine
Research Area

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Indication

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Chemical Information

CAS Number

460330-27-2
Formula Weight

527.673
Molecular Formula

C30H37N7O2
Purity

>98% (HPLC)
Solubility

In Vitro:?DMSO : 50 mg/mL (94.76 mM)
SMILES

COc1ccc2[nH]c(=O)c(cc2c1)C(N1CCN(CC1)C1CCCCC1)c1nnnn1CCc1ccccc1
Chemical Name

——

Shipping & Storage Information

Storage

(-20℃)
Shipping

With Ice Pack
Stability

≥ 2 years

Reference

1.Shan-Meng Lin, et al. Structure-Based Stabilization of Non-native Protein-Protein Interactions of Coronavirus Nucleocapsid Proteins in Antiviral Drug Design. J Med Chem. 2020 Mar 26;63(6):3131-3141.

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