Asimilobine ( —— )

Catalog No. M21801 CAS No. 6871-21-2

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Product Name

Asimilobine
Note

Research use only, not for human use.
Brief Description

Asimilobine is an aporphine isoquinoline alkaloid isolated from plant species of Magnolia obobata Thun.
Description

Asimilobine is an aporphine isoquinoline alkaloid isolated from plant species of Magnolia obobata Thun. Asimilobine is a dopamine biosynthesis inhibitor and a serotonergic receptor antagonist. Asimilobine shows an antimalarial and anti-cancer activity.
In Vitro

Asimilobine (0.05-0.2 μM; for 24 h) shows a significant inhibition of intracellular dopamine levels in a concentration-dependent manner with an IC50 value of 0.13 μM. Asimilobine (0.15 μM) inhibits tyrosine hydroxylase (TH) and aromatic L-amino acid decarboxylase (AADC) activities at 24 h. Asimilobine also decreases TH mRNA levels and intracellular cyclic AMP levels.
In Vivo

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