Glibornuride

CAS No. 26944-48-9

Glibornuride( —— )

Catalog No. M26696 CAS No. 26944-48-9

Glibornuride is a blocker of ATP-sensitive K+ channel(pKi: 5.75). Glibornuride inhibits high affinity [3H]-glibenclamide binding with the potencies expected from their K+ channel activity.

Purity : >98% (HPLC)

COA Datasheet HNMR HPLC MSDS Handing Instructions
Size Price / USD Stock Quantity
1 mL x 10 mM in DMSO 170 In Stock
5MG 155 In Stock
10MG 250 In Stock
25MG 432 In Stock
50MG 600 In Stock
100MG 830 In Stock
200MG Get Quote In Stock
500MG Get Quote In Stock
1G Get Quote In Stock

Biological Information

  • Product Name
    Glibornuride
  • Note
    Research use only, not for human use.
  • Brief Description
    Glibornuride is a blocker of ATP-sensitive K+ channel(pKi: 5.75). Glibornuride inhibits high affinity [3H]-glibenclamide binding with the potencies expected from their K+ channel activity.
  • Description
    Glibornuride is a blocker of ATP-sensitive K+ channel(pKi: 5.75). Glibornuride inhibits high affinity [3H]-glibenclamide binding with the potencies expected from their K+ channel activity.(In Vivo):The diabetic group, given Glibornuride(5mg/kg), blood glucose, serum alkaline phosphatase activity, serum sialic acid, uric acid, potassium, and liver NEG levels decreased, but liver LPO, GSH, serum sodium levels, and body weight increased.
  • In Vitro
    ——
  • In Vivo
    Animal Model:6-6.5-month-old male Swiss Albino rats, weighing 150-200 g Dosage:5 mg/kg Administration:Given by gavage, daily for 28 days Result:Administration for 28 days caused an increase in body weights in the diabetic groups. Treatment for 28 days decreased the serum uric acid levels in diabetic rats.
  • Synonyms
    ——
  • Pathway
    Cell Cycle/DNA Damage
  • Target
    Potassium Channel
  • Recptor
    ——
  • Research Area
    ——
  • Indication
    ——

Chemical Information

  • CAS Number
    26944-48-9
  • Formula Weight
    366.48
  • Molecular Formula
    C18H26N2O4S
  • Purity
    >98% (HPLC)
  • Solubility
    In Vitro:?DMSO : 250 mg/mL (682.17 mM)
  • SMILES
    [H][C@@]12CC[C@@](C)([C@@H](O)[C@H]1NC(=O)NS(=O)(=O)c1ccc(C)cc1)C2(C)C
  • Chemical Name
    ——

Shipping & Storage Information

  • Storage
    (-20℃)
  • Shipping
    With Ice Pack
  • Stability
    ≥ 2 years

Reference

1.Cheng Y, et al. 4-Methoxyestradiol-induced oxidative injuries in human lung epithelial cells. Toxicol Appl Pharmacol. 2007 May 1;220(3):271-7.
molnova catalog
related products
  • Nateglinide

    Nateglinide is an oral antihyperglycemic agent used for the treatment of non-insulin-dependent diabetes mellitus (NIDDM).

  • BMS-191011

    BMS-191011 is an activator of large-conductance calcium-activated potassium (BKCa) channels effective in stroke models.

  • Charybdotoxin

    Specific inhibitor of the big conductance Ca2+-activated K+ channel.