Ercalcidiol( 25-hydroxy Vitamin D2 )

Catalog No. M26679 CAS No. 21343-40-8

COA

Datasheet

HNMR

HPLC

MSDS

Handing Instructions

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Product Name

Ercalcidiol
Note

Research use only, not for human use.
Brief Description

Ercalcidiol is a metabolite of vitamin D2 and can be used in monitoring vitamin D therapy.
Description

Ercalcidiol is a metabolite of vitamin D2 and can be used in monitoring vitamin D therapy.(In Vitro):The half-life of Ercalcidiol is shorter than that of 25(OH)D3 and Ercalcidiol binds less well to the vitamin D binding protein, making Ercalcidiol less potent and required much higher doses than vitamin D3 .
In Vitro

Differentiation between Ercalcidiol (25(OH)D2) and 25(OH)D3 is important for monitoring vitamin D therapy, as vitamin D2 is the predominant prescription form. The half-life of Ercalcidiol is shorter than that of 25(OH)D3 and it binds less well to the vitamin D binding protein, making it less potent and, therefore, required to be administered at much higher doses than vitamin D3. Some currently used assays have a diminished capacity to detect Ercalcidiol, which can lead to dangerous overdosing when attempting to monitor therapy with vitamin D2.
In Vivo

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Synonyms

25-hydroxy Vitamin D2
Pathway

Proteasome/Ubiquitin
Target

Endogenous Metabolite
Recptor

RUVBL1/2
Research Area

——
Indication

——

CAS Number

21343-40-8
Formula Weight

412.658
Molecular Formula

C28H44O2
Purity

>98% (HPLC)
Solubility

In Vitro:?DMSO : 200 mg/mL (484.67 mM)
SMILES

[H][C@@]12CC[C@H]([C@H](C)\C=C\[C@H](C)C(C)(C)O)[C@@]1(C)CCC\C2=C/C=C1/C[C@@H](O)CCC1=C
Chemical Name

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1.Assimon VA, et al. CB-6644 Is a Selective Inhibitor of the RUVBL1/2 Complex with Anticancer Activity. ACS Chem Biol. 2019 Feb 15;14(2):236-244.

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