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Darodipine
CAS No. 72803-02-2
Darodipine( PY 108-068 | PY-108068 )
Catalog No. M26661 CAS No. 72803-02-2
Darodipine is a dihydropyridine type Ca+2 antagonist.
Purity : >98% (HPLC)
COA
Datasheet
HNMR
HPLC
MSDS
Handing Instructions
| Size | Price / USD | Stock | Quantity |
| 1 mL x 10 mM in DMSO | 130 | In Stock |
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| 2MG | 74 | In Stock |
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| 5MG | 106 | In Stock |
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| 10MG | 149 | In Stock |
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| 25MG | 274 | In Stock |
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| 50MG | 462 | In Stock |
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| 100MG | Get Quote | In Stock |
|
| 200MG | Get Quote | In Stock |
|
| 500MG | Get Quote | In Stock |
|
| 1G | Get Quote | In Stock |
|
Biological Information
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Product NameDarodipine
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NoteResearch use only, not for human use.
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Brief DescriptionDarodipine is a dihydropyridine type Ca+2 antagonist.
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DescriptionDarodipine is a dihydropyridine type Ca+2 antagonist.(In Vivo):Darodipine may reduce neuronal cytoskeletal changes occurring in aging and in neurodegenerative disorders. Darodipine (10 mg/kg; 6-month (from the 18th to the 24th month of life); p.o.) treatment restores in part the expression of 200 kDa-NF subunit immunoreactivity in the cerebellar cortex. Treatment with darodipine increases the number and the average length of alkaline phosphatase-reactive capillaries and reduces the intercapillary distance and the diameter of cerebral capillaries in old rats. The pericapillary microrenvironment of the Ammon’s horn is the most sensitive to treatment with darodipine.
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In Vitro——
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In VivoTreatment with darodipine increases the number and the average length of alkaline phosphatase-reactive capillaries and reduces the intercapillary distance and the diameter of cerebral capillaries in old rats. The pericapillary microrenvironment of the Ammon’s horn is the most sensitive to treatment with darodipine. Darodipine may reduce neuronal cytoskeletal changes occurring in aging and in neurodegenerative disorders. A 6-month treatment (from the 18th to the 24th month of life) with an oral daily dose of 10 mg/kg of darodipine restores in part the expression of 200 kDa-NF subunit immunoreactivity in the cerebellar cortex.
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SynonymsPY 108-068 | PY-108068
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PathwayGPCR/G Protein
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TargetCalcium Channel
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RecptormAChR
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Research Area——
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Indication——
Chemical Information
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CAS Number72803-02-2
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Formula Weight371.393
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Molecular FormulaC19H21N3O5
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Purity>98% (HPLC)
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Solubility——
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SMILESCCOC(=O)C1=C(C)NC(C)=C(C1c1cccc2nonc12)C(=O)OCC
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Chemical Name——
Shipping & Storage Information
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Storage(-20℃)
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ShippingWith Ice Pack
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Stability≥ 2 years
Reference
1.M Das, D K Ganguly, et al. Enhancement by oxotremorine of acetylcholine release from the rat phrenic nerve. Br J Pharmacol. 1978 Feb;62(2):195-8.
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