Orexin 2 Receptor Agonist( MDK-5220 | MDK5220. Orexin2 receptor agonist )

Catalog No. M17380 CAS No. 1796565-52-0

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Product Name

Orexin 2 Receptor Agonist
Note

Research use only, not for human use.
Brief Description

Orexin 2 Receptor Agonist is an effective (EC50: 23 nM) and OX2R-selective (OX1R/OX2R EC50 ratio: 70) agonist.
Description

MDK-5220 is a potent ans selective Orexin2 receptor agonist. MDK-5220 has CAS#1796565-52-0, which has previously no designed code name. For the convenience of communication, MedKoo temporally names it as MDK-5220 (note: 5220 is the last four digit of its CAS#). MDK-5220 was reported in WO2015088000. MDK-5220 exhibits an orexin agonist activity and is expected to be useful as an excellent therapeutic or preventive agent for narcolepsy.
In Vitro

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In Vivo

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Synonyms

MDK-5220 | MDK5220. Orexin2 receptor agonist
Pathway

Cell Cycle/DNA Damage
Target

ROCK
Recptor

O2XR
Research Area

Neurological Disease
Indication

——

CAS Number

1796565-52-0
Formula Weight

586.7
Molecular Formula

C32H34N4O5S
Purity

>98% (HPLC)
Solubility

DMSO : ≥ 32 mg/mL; 54.54 mM
SMILES

c1(cccc(c1)C(=O)N(C)C)c1ccc(c(c1)S(=O)(=O)Nc1cccc(c1)NCCNC(=O)c1cc(ccc1)C)OC
Chemical Name

4'-methoxy-N,N-dimethyl-3'-(N-(3-((2-(3-methylbenzamido)ethyl)amino)phenyl)sulfamoyl)-[1,1'-biphenyl]-3-carboxamide

1. Nagahara T, et al. J Med Chem. 2015 Oct 22;58(20):7931-7.

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