Asoxime dichloride

Research use only, not for human use.

Asoxime dichloride (HI-6) is an antagonist to acetylcholine receptors (AChRs) including the nicotinic receptor, α7 nAChR.

Asoxime dichloride (HI-6) is an antagonist to acetylcholine receptors (AChRs) including the nicotinic receptor, α7 nAChR. Asoxime dichloride (HI-6) can be used as an antigen and improves vaccination efficacy in the nervous system. Asoxime dichloride involves in modulating immunity response.(In Vivo):A combination of HI-6 and keyhole limpet hemocyanin (KLH) produces a vaccination of almost the same efficacy as that for Freund's complete adjuvant. Asoxime dichloride (intramuscular injection into the rear limb; 2% and 0.2% of median lethal dose 15.6 and 1.56 mg/kg; 21 or 65 days) significantly improved vaccination efficacy as a dose-dependent manner when KLH is 1 mg/kg.

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Asoxime dichloride (intramuscular injection into the rear limb; 2% and 0.2% of median lethal dose 15.6 and 1.56 mg/kg; 21 or 65 days) significantly improved vaccination efficacy as a dose-dependent manner when KLH is 1?mg/kg. A combination of HI-6 and keyhole limpet hemocyanin (KLH) produces a vaccination of almost the same efficacy as that for Freund's complete adjuvant. Animal Model:Balb/c mice Dosage:2% and 0.2% of median lethal dose 15.6 and 1.56mg/kg Administration:Intramuscular injection into the rear limb Result:Improved vaccination efficacy at the level of immunity regulation by the nervous system.

HI-6 | Asoxime (dichloride) | Tert-Butyl2-(2-hydroxyethyl)-1-pyrrolidinecarboxylate

Cell Cycle/DNA Damage

AChR

5-HT7| H1 receptor| α2A-adrenergic receptor| α2B-adrenergic receptor| α2C-adrenergic receptor

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34433-31-3

359.21

C14H16Cl2N4O3

>98% (HPLC)

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[Cl-].[Cl-].NC(=O)c1cc[n+](COC[n+]2ccccc2\C=N\O)cc1

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(-20℃)

With Ice Pack

≥ 2 years