2-Arachidonoylglycerol

Research use only, not for human use.

2-Arachidonoylglycerol activates neuronal cannabinoid receptors as a full agonist, and prevents the induction of long-term potentiation at CA3–CA1 synapses.

2-Arachidonoylglycerol activates neuronal cannabinoid receptors as a full agonist, and prevents the induction of long-term potentiation at CA3–CA1 synapses.(In Vitro):The CB1 receptor agonist WIN-55212-2 (3 μM) inhibited forskolin-induced cAMP accumulation, an effect that was reverted by the CB1 antagonist SR-141716 (1 μM) or by pertussis toxin. 2-Arachidonoylglycerol (10 μM) elicited a quantitatively similar inhibition which was also sensitive to SR-141716 and pertussis toxin. This effect occurred with a potency (IC50 = 0.8 μM) consistent with the affinity of 2-Arachidonoylglycerol for CB1 receptors (Ki = 0.7–2.4 μM) and comparable to the potency of anandamide (IC50 = 1.2 μM).

2-Arachidonylglycerol (2-AG) is a cannabinoid ligand isolated from intestinal tissue. 2-Arachidonoylglycerol activates neuronal cannabinoid receptors as a full agonist, and prevents the induction of long-term potentiation at CA3-CA1 synapses. 2-Arachidonoylglycerol binds to cannabinoid receptors and exerts several effects typical of cannabinoid drugs.

——

——

GPCR/G Protein

Cannabinoid Receptor

DNA/RNA Synthesis

——

——

53847-30-6

378.553

C23H38O4

>98% (HPLC)

——

CCCCC\C=C/C\C=C/C\C=C/C\C=C/CCCC(=O)OC(CO)CO

——

(-20℃)

With Ice Pack

≥ 2 years