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2-Arachidonoylglycerol
CAS No. 53847-30-6
2-Arachidonoylglycerol( —— )
Catalog No. M26591 CAS No. 53847-30-6
2-Arachidonoylglycerol activates neuronal cannabinoid receptors as a full agonist, and prevents the induction of long-term potentiation at CA3–CA1 synapses.
Purity : >98% (HPLC)
COA
Datasheet
HNMR
HPLC
MSDS
Handing Instructions
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Biological Information
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Product Name2-Arachidonoylglycerol
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NoteResearch use only, not for human use.
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Brief Description2-Arachidonoylglycerol activates neuronal cannabinoid receptors as a full agonist, and prevents the induction of long-term potentiation at CA3–CA1 synapses.
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Description2-Arachidonoylglycerol activates neuronal cannabinoid receptors as a full agonist, and prevents the induction of long-term potentiation at CA3–CA1 synapses.(In Vitro):The CB1 receptor agonist WIN-55212-2 (3 μM) inhibited forskolin-induced cAMP accumulation, an effect that was reverted by the CB1 antagonist SR-141716 (1 μM) or by pertussis toxin. 2-Arachidonoylglycerol (10 μM) elicited a quantitatively similar inhibition which was also sensitive to SR-141716 and pertussis toxin. This effect occurred with a potency (IC50 = 0.8 μM) consistent with the affinity of 2-Arachidonoylglycerol for CB1 receptors (Ki = 0.7–2.4 μM) and comparable to the potency of anandamide (IC50 = 1.2 μM).
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In Vitro2-Arachidonylglycerol (2-AG) is a cannabinoid ligand isolated from intestinal tissue. 2-Arachidonoylglycerol activates neuronal cannabinoid receptors as a full agonist, and prevents the induction of long-term potentiation at CA3-CA1 synapses. 2-Arachidonoylglycerol binds to cannabinoid receptors and exerts several effects typical of cannabinoid drugs.
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In Vivo——
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Synonyms——
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PathwayGPCR/G Protein
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TargetCannabinoid Receptor
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RecptorDNA/RNA Synthesis
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Research Area——
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Indication——
Chemical Information
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CAS Number53847-30-6
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Formula Weight378.553
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Molecular FormulaC23H38O4
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Purity>98% (HPLC)
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Solubility——
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SMILESCCCCC\C=C/C\C=C/C\C=C/C\C=C/CCCC(=O)OC(CO)CO
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Chemical Name——
Shipping & Storage Information
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Storage(-20℃)
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ShippingWith Ice Pack
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Stability≥ 2 years
Reference
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Hemopressin (human, ...
Bioactive endogenous peptide substrate for endopeptidase 24.15 (ep24.15), neurolysin (ep24.16) and ACE. Ki values are 27.76, 3.43 and 1.87 μM respectively. Potent hypotensive in vivo. Also acts as a selective CB1 receptor inverse agonist. Displays antinociceptive activity in vivo.
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Otenabant
A potent, and selective CB1 receptor antagonist with Ki of 0.7 nM/0.12 nM in binding and functional assays respectively; has low affinity (Ki=7600 nM) for human CB2 receptors; reverses cannabinoid agonist mediated responses, reduces food intake, and increases energy expenditure and fat oxidation in rodents.ObesityPhase 3 Discontinued
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LY2828360
LY2828360 is a cannabinoid (CB) receptor 2 agonist (Ki = 40.3 nM). It selectively activates CB2 over CB1 in a GTPγS binding assay (EC50s = 20.1 and >100000 nM respectively).
