Reparixin is a potent inhibitor of both CXCL8 receptors?CXCR1/2, it inhibits weakly?CXCR2-mediated cell migration (IC50=100 nM), whereas it strongly blocks?CXCR1-mediated chemotaxis (IC50=1 nM).

Bioactive endogenous peptide substrate for endopeptidase 24.15 (ep24.15), neurolysin (ep24.16) and ACE. Ki values are 27.76, 3.43 and 1.87 μM respectively. Potent hypotensive in vivo. Also acts as a selective CB1 receptor inverse agonist. Displays antinociceptive activity and induces hypophagia in vivo.

N-Oleoyl glycine, a lipoamino acid, was able to promote 3T3-L1 adipogenesis through the activation of CB1 receptor and the enhancement of insulin-mediated Akt signaling pathway.