Thevetiaflavone

Research use only, not for human use.

Thevetiaflavone could up-regulate the expression of Bcl 2 and down-regulate that of Bax and caspase 3.

Thevetiaflavone could up-regulate the expression of Bcl 2 and down-regulate that of Bax and caspase 3.(In Vitro):Thevetiaflavone reduces ROS overproduction and ameliorates ROS-mediated mitochondrial dysfunction, including collapse of mitochondrial membrane potential and opening of mitochondrial permeability transition pores, thereby reducing intracellular Ca2+ levels. Thevetiaflavone up-regulates the expression of Bcl-2, down-regulates the expression of Bax and caspase-3 and increases the activity of caspase-3 to inhibit the apoptosis of PC12 cells.

Thevetiaflavone, a natural flavonoid obtained from Wikstroemia indica, could improve cell viability and suppresses the leakage of lactate dehydrogenase from the cytoplasm. Further investigation of the mechanisms demonstrated that Thevetiaflavone decreases overproduction of ROS and ameliorates ROS-mediated mitochondrial dysfunction, including collapse of mitochondrial membrane potential and mitochondrial permeability transition pore opening. Thevetiaflavone reduces the intracellular Ca2+ level, which is closely associated with mitochondrial function and interplays with ROS. Furthermore, Thevetiaflavone inhibits apoptosis in PC12 cells through upregulating the expression of Bcl-2 and downregulating that of Bax and caspase-3 in addition to increasing the activity of caspase-3. These results further indicate the protective effects of thevetiaflavone in vivo and its application in the clinic.

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Apigenin-5-methyl ether | 2-Genistein-5-methyl ether

Angiogenesis

Bcl-2

5-Lipoxygenase| prostaglandin synthetase (PGS)

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29376-68-9

284.267

C16H12O5

>98% (HPLC)

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COc1cc(O)cc2oc(cc(=O)c12)-c1ccc(O)cc1

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(-20℃)

With Ice Pack

≥ 2 years