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BDA-366
CAS No. 1909226-00-1
BDA-366( NSC-639366 | NSC639366 | BDA366 )
Catalog No. M12991 CAS No. 1909226-00-1
A potent, selective Bcl2 BH4 domain antagonist with Ki of 3.3 nM; shows no affinity for other Bcl2 family members, including Bcl-XL, Mcl-1, or Bfl-1/A1.
Purity : >98% (HPLC)
COA
Datasheet
HNMR
HPLC
MSDS
Handing Instructions
| Size | Price / USD | Stock | Quantity |
| 2MG | 102 | In Stock |
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| 5MG | 165 | In Stock |
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| 10MG | 280 | In Stock |
|
| 25MG | 471 | In Stock |
|
| 50MG | 683 | In Stock |
|
| 100MG | 954 | In Stock |
|
| 200MG | Get Quote | In Stock |
|
| 500MG | Get Quote | In Stock |
|
| 1G | Get Quote | In Stock |
|
Biological Information
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Product NameBDA-366
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NoteResearch use only, not for human use.
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Brief DescriptionA potent, selective Bcl2 BH4 domain antagonist with Ki of 3.3 nM; shows no affinity for other Bcl2 family members, including Bcl-XL, Mcl-1, or Bfl-1/A1.
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DescriptionA potent, selective Bcl2 BH4 domain antagonist with Ki of 3.3 nM; shows no affinity for other Bcl2 family members, including Bcl-XL, Mcl-1, or Bfl-1/A1; induces apoptotic cell death in a Bax-dependent manner, and induces calcium (Ca2+) release via inhibition of Bcl2/IP3R interaction; potently represses lung cancer in vivo, and induces Bcl2 conformational change in tumor tissues.
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In Vitro——
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In Vivo——
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SynonymsNSC-639366 | NSC639366 | BDA366
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PathwayAngiogenesis
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TargetBcl-2
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RecptorBcl-2
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Research AreaCancer
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Indication——
Chemical Information
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CAS Number1909226-00-1
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Formula Weight423.5
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Molecular FormulaC24H29N3O4
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Purity>98% (HPLC)
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Solubility——
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SMILESCCN(CC)CC(CNC1=C2C(=C(C=C1)NCC3CO3)C(=O)C4=CC=CC=C4C2=O)O
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Chemical Name1-(((S)-3-(diethylamino)-2-hydroxypropyl)amino)-4-((((S)-oxiran-2-yl)methyl)amino)anthracene-9,10-dione
Shipping & Storage Information
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Storage(-20℃)
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ShippingWith Ice Pack
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Stability≥ 2 years
Reference
1. Han B, et al. Cancer Cell. 2015 Jun 8;27(6):852-63.
2. Deng J, et al. Oncotarget. 2016 May 10;7(19):27753-63.
3. Vervloessem T, et al. Aging (Albany NY). 2015 Oct;7(10):748-9.
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