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2-(Methylamino)-1H-purin-6(7H)-one
CAS No. 10030-78-1
2-(Methylamino)-1H-purin-6(7H)-one( N2-methylguanine )
Catalog No. M26576 CAS No. 10030-78-1
2-(Methylamino)-1H-purin-6(7H)-one is an endogenous methylated nucleoside found in human fluids and a modified nucleoside.
Purity : >98% (HPLC)
COA
Datasheet
HNMR
HPLC
MSDS
Handing Instructions
| Size | Price / USD | Stock | Quantity |
| 5MG | 103 | In Stock |
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| 10MG | 154 | In Stock |
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| 25MG | 262 | In Stock |
|
| 50MG | 365 | In Stock |
|
| 100MG | 538 | In Stock |
|
| 200MG | 768 | In Stock |
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| 500MG | Get Quote | In Stock |
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| 1G | Get Quote | In Stock |
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Biological Information
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Product Name2-(Methylamino)-1H-purin-6(7H)-one
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NoteResearch use only, not for human use.
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Brief Description2-(Methylamino)-1H-purin-6(7H)-one is an endogenous methylated nucleoside found in human fluids and a modified nucleoside.
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Description2-(Methylamino)-1H-purin-6(7H)-one is an endogenous methylated nucleoside found in human fluids and a modified nucleoside.(In Vitro):2-(Methylamino)-1H-purin-6(7H)-one is the principal kinetic barrier for reverse transcription in the 1340 bases proximal to the 5' end of E. coli 16S rRNA. Transcription intermediates correspond to attenuation at the positions of 2-(Methylamino)-1H-purin-6(7H)-one in the rRNA sequence. The relaxation time for elongation of the cDNA through m2G is approximately 3 min. 2-(Methylamino)-1H-purin-6(7H)-one is found within both helical and looped regions of RNA secondary structure, and it can exist in either the s-cis or the s-trans rotamer. If there is a rotational preference for the methyl group, the effect of 2-(Methylamino)-1H-purin-6(7H)-one substitution may be specific to the sequence context depending upon which face of the base participates in hydrogen bonding.
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In Vitro2-(Methylamino)-1H-purin-6(7H)-one (N2-methylguanine) is found within both helical and looped regions of RNA secondary structure, and it can exist in either the s-cis or the s-trans rotamer. If there is a rotational preference for the methyl group, the effect of 2-(Methylamino)-1H-purin-6(7H)-one substitution may be specific to the sequence context depending upon which face of the base participates in hydrogen bonding. 2-(Methylamino)-1H-purin-6(7H)-one (N2-methylguanine) is the principal kinetic barrier for reverse transcription in the 1340 bases proximal to the 5' end of E. coli 16S rRNA. Transcription intermediates correspond to attenuation at the positions of 2-(Methylamino)-1H-purin-6(7H)-one in the rRNA sequence. The relaxation time for elongation of the cDNA through m2G is approximately 3 min.
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In Vivo——
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SynonymsN2-methylguanine
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PathwayCell Cycle/DNA Damage
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TargetDNA/RNA Synthesis
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RecptorCYP3A
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Research Area——
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Indication——
Chemical Information
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CAS Number10030-78-1
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Formula Weight165.156
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Molecular FormulaC6H7N5O
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Purity>98% (HPLC)
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SolubilityIn Vitro:?DMSO : 1 mg/mL (6.06 mM)
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SMILESCNc1nc(=O)c2[nH]cnc2[nH]1
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Chemical Name——
Shipping & Storage Information
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Storage(-20℃)
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ShippingWith Ice Pack
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Stability≥ 2 years
Reference
1.Method for increasing HDL cholesterol levels?using?heteroaromatic phenylmethanes. United States Patent 6103733
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