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CDDO-2P-Im
CAS No. 1883650-96-1
CDDO-2P-Im( CDDO-2-P-Im )
Catalog No. M26555 CAS No. 1883650-96-1
CDDO-2P-Im, an analog of CDDO-Imidazolide, has a chemopreventive effect. It can reduce the size and severity of the lung tumors in the mouse lung cancer model.
Purity : >98% (HPLC)
COA
Datasheet
HNMR
HPLC
MSDS
Handing Instructions
| Size | Price / USD | Stock | Quantity |
| 1 mL x 10 mM in DMSO | 297 | In Stock |
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| 5MG | 217 | In Stock |
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| 10MG | 353 | In Stock |
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| 25MG | 584 | In Stock |
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| 50MG | 808 | In Stock |
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| 100MG | 1088 | In Stock |
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| 200MG | 1460 | In Stock |
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| 500MG | Get Quote | In Stock |
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| 1G | Get Quote | In Stock |
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Biological Information
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Product NameCDDO-2P-Im
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NoteResearch use only, not for human use.
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Brief DescriptionCDDO-2P-Im, an analog of CDDO-Imidazolide, has a chemopreventive effect. It can reduce the size and severity of the lung tumors in the mouse lung cancer model.
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DescriptionCDDO-2P-Im, an analog of CDDO-Imidazolide, has a chemopreventive effect. It can reduce the size and severity of the lung tumors in the mouse lung cancer model.(In Vitro):In RAW264.7 cells, CDDO-2P-Im suppresses NO production (IC50: 5.8 nM). CDDO-2P-Im (100 nM) induces differentiation of U937 cells.(In Vivo):CDDO-2P-Im significantly elevates heme oxygenase-1 and quinone reductase mRNA and protein levels. In A/J mice, CDDO-2P-Im (50-200 mg/kg) decreases the number, size, and severity of tumors.
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In VitroCDDO-2P-Im (100 nM; 4 days) induces differentiation of U937 cells at 100 nM.CDDO-2P-Im suppresses NO production in RAW264.7 cells with an IC50 of 5.8 nM. Apoptosis Analysis Cell Line:U937 cells Concentration:30 nM, 100 nM Incubation Time:4 days Result:Induced differentiation of U937 cells at 100 nM.
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In VivoCDDO-2P-Im is more stable than CDDO-Im in pharmacokinetic studies.CDDO-2P-Im significantly elevates heme oxygenase-1 (HO-1) and quinone reductase (NQO1) mRNA and protein levels in various mouse tissues in vivo.CDDO-2P-Im (50-200 mg/kg; diet; for 16 weeks) decreases the number, the size and the severity of tumors in A/J mice. Animal Model:Seven week-old female A/J mice Dosage:50 mg/kg, 200 mg/kg Administration: Diet; for 16 weeks Result:Decreased the number, the size and the severity of tumors.
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SynonymsCDDO-2-P-Im
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PathwayOthers
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TargetOther Targets
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Recptor——
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Research Area——
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Indication——
Chemical Information
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CAS Number1883650-96-1
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Formula Weight618.822
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Molecular FormulaC39H46N4O3
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Purity>98% (HPLC)
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SolubilityIn Vitro:?DMSO : 200 mg/mL (323.20 mM)
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SMILES[H][C@@]12CC(C)(C)CC[C@@]1(CC[C@]1(C)[C@]2([H])C(=O)C=C2[C@@]3(C)C=C(C#N)C(=O)C(C)(C)[C@]3([H])CC[C@@]12C)C(=O)n1cnc(c1)-c1ccccn1
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Chemical Name——
Shipping & Storage Information
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Storage(-20℃)
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ShippingWith Ice Pack
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Stability≥ 2 years
Reference
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GW604714X?
GW604714X were found to be potent inhibitors of mitochondrial respiration supported by pyruvate.
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Argipressin acetate ...
Vasopressin acetate is a peptide hormone with vasoconstrictive and antidiuretic activities that binds to the vascular arginine vasopressin receptor, V1, with Kd values of 1.31 and 1.44 nM in A7r5 rat aortic smooth muscle cells and neonatal rat cardiomyocytes, respectively
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Crustacean Cardioact...
Crustacean cardioactive peptide (CCAP) is a highly conserved, amidated cyclic nonapeptide with the primary structure PFCNAFTGC-NH2 (ProPheCysAsnAlaPheTyrGlyCys-NH2) and a disulfide bridge between Cys3 and Cys9. It is found in crustaceans and insects where it behaves as a cardioaccelerator, neuropeptide transmitter for other areas of the nervous system and a hormone.
