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ZM223
CAS No. 2031177-48-5
ZM223( ZM-223 )
Catalog No. M26524 CAS No. 2031177-48-5
ZM223 is a potent non-covalent inhibitor of NEDD8 activating enzyme (NAE).
Purity : >98% (HPLC)
COA
Datasheet
HNMR
HPLC
MSDS
Handing Instructions
| Size | Price / USD | Stock | Quantity |
| 2MG | 264 | Get Quote |
|
| 5MG | 403 | Get Quote |
|
| 10MG | 592 | Get Quote |
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| 25MG | 888 | Get Quote |
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| 50MG | 1242 | Get Quote |
|
| 100MG | 1701 | Get Quote |
|
| 500MG | 3402 | Get Quote |
|
| 1G | Get Quote | Get Quote |
|
Biological Information
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Product NameZM223
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NoteResearch use only, not for human use.
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Brief DescriptionZM223 is a potent non-covalent inhibitor of NEDD8 activating enzyme (NAE).
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DescriptionZM223 is a potent non-covalent inhibitor of NEDD8 activating enzyme (NAE).(In Vitro):ZM223 (0.1-1 μM) inhibits cell growth with IC50s of 100 and 122 nM in HCT-116 and U-2OS cancer cells, respectively. ZM223 (0.1-1 μM) dose-dependently reduces the level of NEDD8 and accumulation of the UBC12 protein thereby reducing the subsequent NEDD8-UBC12 complex.
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In VitroZM223 (0.1-1 μM; 4 hours) inhibits both HCT-116 and U-2OS cancer cells with IC50s of 100 and 122 nM, respectively.ZM223 (0.1-1 μM; 4 hours) causes a dose-response decrease in the level of NEDD8 and accumulation of the UBC12 protein, indicating the decrease of the subsequent NEDD8-UBC12 complex.Cell Viability Assay Cell Line:HCT116 colon cancer cells and U-2OS osteosarcoma cells Concentration:0.1 μM, 1 μM Incubation Time:4 hours Result:Inhibited both HCT-116 and U-2OS cancer cells.Western Blot Analysis Cell Line:HCT116 colon cancer cells Concentration:0.1 μM, 1 μM Incubation Time:4 hours Result:Caused a decrease in the level of NEDD8 and an increase in the downstream UBC12 protein.
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In Vivo——
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SynonymsZM-223
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PathwayChromatin/Epigenetic
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TargetEpigenetic Reader Domain
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RecptorEGFR
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Research Area——
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Indication——
Chemical Information
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CAS Number2031177-48-5
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Formula Weight502.53
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Molecular FormulaC23H17F3N4O2S2
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Purity>98% (HPLC)
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SolubilityIn Vitro:?DMSO : 83.33 mg/mL (165.82 mM)
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SMILESNc1ccc(SCC(=O)Nc2ccc3nc(NC(=O)c4ccc(cc4)C(F)(F)F)sc3c2)cc1
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Chemical Name——
Shipping & Storage Information
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Storage(-20℃)
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ShippingWith Ice Pack
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Stability≥ 2 years
Reference
1.Sargeant P, Farndale RW, Sage SO. ADP- and thapsigargin-evoked Ca2+ entry and protein-tyrosine phosphorylation are inhibited by the tyrosine kinase inhibitors genistein and methyl-2,5-dihydroxycinnamate in fura-2-loaded human platelets. J Biol Chem. 1993 Aug 25;268(24):18151-6.
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