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Zandelisib

CAS No. 1401436-95-0

Zandelisib( ME-401 | PWT-143 )

Catalog No. M26519 CAS No. 1401436-95-0

Zandelisib is an inhibitor of phosphatidylinositol 3-kinase (PI3K)(p110δ, IC50 of 3.5 nM), and with antineoplastic activity.

Purity : >98% (HPLC)

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Biological Information

Product Name

Zandelisib
Note

Research use only, not for human use.
Brief Description

Zandelisib is an inhibitor of phosphatidylinositol 3-kinase (PI3K)(p110δ, IC50 of 3.5 nM), and with antineoplastic activity.
Description

Zandelisib is an inhibitor of phosphatidylinositol 3-kinase (PI3K)(p110δ, IC50 of 3.5 nM), and with antineoplastic activity.(In Vitro):Zandelisib inhibits PI3Ks(p110α, p110β, p110γ and p110δ with IC50s of 4, 976 nM, 605 nM, 817 nM and 3.5 nM, respectivey).
In Vitro

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In Vivo

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Synonyms

ME-401 | PWT-143
Pathway

PI3K/Akt/mTOR signaling
Target

PI3K
Recptor

Apoptosis
Research Area

——
Indication

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Chemical Information

CAS Number

1401436-95-0
Formula Weight

576.697
Molecular Formula

C31H38F2N8O
Purity

>98% (HPLC)
Solubility

In Vitro:?DMSO : 33.33 mg/mL (57.80 mM)
SMILES

CN1CCC(CC1)c1ccccc1CC(C)(C)Nc1nc(nc(n1)-n1c(nc2ccccc12)C(F)F)N1CCOCC1
Chemical Name

——

Shipping & Storage Information

Storage

(-20℃)
Shipping

With Ice Pack
Stability

≥ 2 years

Reference

1.Llado V, et al. Minerval induces apoptosis in Jurkat and other cancer cells. J Cell Mol Med. 2010 Mar;14(3):659-70.

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