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XY101

CAS No. 2349368-16-5

XY101( —— )

Catalog No. M26510 CAS No. 2349368-16-5

XY101 is a selective, metabolically stable and orally available agonist of RORγ inverse(IC50 of 30 nM and a Kd of 380 nM).

Purity : >98% (HPLC)

COA Datasheet HNMR HPLC MSDS Handing Instructions
Size Price / USD Stock Quantity
1 mL x 10 mM in DMSO 204 In Stock
5MG 164 In Stock
10MG 283 In Stock
25MG 451 In Stock
50MG 631 In Stock
100MG 848 In Stock
200MG Get Quote In Stock
500MG 1655 In Stock
1G Get Quote In Stock
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Biological Information

  • Product Name
    XY101
  • Note
    Research use only, not for human use.
  • Brief Description
    XY101 is a selective, metabolically stable and orally available agonist of RORγ inverse(IC50 of 30 nM and a Kd of 380 nM).
  • Description
    XY101 is a selective, metabolically stable and orally available agonist of RORγ inverse(IC50 of 30 nM and a Kd of 380 nM).(In Vitro):XY101 effectively inhibits cell growth, colony formation and expression of androgen receptor (AR), AR-V7 and prostate specific antigen (PSA).(In Vivo):XY101 exhibits significant antitumor activities during the treatment period with tumor growth inhibition and is well tolerated without obvious body weight loss.
  • In Vitro
    XY101 potently inhibits cell growth, colony formation, and the expression of androgen receptor (AR), AR-V7 and prostate-specific antigen (PSA).
  • In Vivo
    XY101 exhibits significant antitumor activities during the treatment period with tumor growth inhibition and is well tolerated without obvious body weight loss.
  • Synonyms
    ——
  • Pathway
    Others
  • Target
    Other Targets
  • Recptor
    α-synuclein
  • Research Area
    ——
  • Indication
    ——

Chemical Information

  • CAS Number
    2349368-16-5
  • Formula Weight
    563.49
  • Molecular Formula
    C25H20F7NO4S
  • Purity
    >98% (HPLC)
  • Solubility
    In Vitro:?DMSO : 250 mg/mL (443.67 mM)
  • SMILES
    CCS(=O)(=O)c1ccc(CC(=O)Nc2ccc(cc2)-c2ccc(cc2F)C(O)(C(F)(F)F)C(F)(F)F)cc1
  • Chemical Name
    ——

Shipping & Storage Information

  • Storage
    (-20℃)
  • Shipping
    With Ice Pack
  • Stability
    ≥ 2 years

Reference

1.Pujols J, et al. Small molecule inhibits α-synuclein aggregation, disrupts amyloid fibrils, and prevents degeneration of dopaminergic neurons. Proc Natl Acad Sci U S A. 2018 Oct 9;115(41):10481-10486.
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