SR10067

Research use only, not for human use.

SR10067 is a potent, selective and brain penetrant agonist of Rev-Erbβ(IC50 = 160 nM) and Rev-Erbα(IC50 = 170 nM) with anxiolytic activity.

SR10067 is a potent, selective and brain penetrant agonist of Rev-Erbβ(IC50 = 160 nM) and Rev-Erbα(IC50 = 170 nM) with anxiolytic activity.

SR10067 has high affinity for Rev-Erbβ and Rev-Erbαwith IC50 values are 160 and 170 nM, respectively.

SR10067 (i.p.; 30 mg/kg) has good pharmacokinetic properties in mouse. Animal Model:Mice Dosage:30 mg/kg Administration:i.p.Result:Remained above the IC50 of the receptor in plasma and brain concentrations. Suppressed the circadian rhythm of Npas2 gene expression in the mouse hypothalamus in a single injection and had a dose-dependent effect on reduction in nocturnal wheel running activity. Induced wakefulness and reduced SWS and REM sleep and displayed high anxiolytic activity.

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Others

Other Targets

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1380548-02-6

465.593

C31H31NO3

>98% (HPLC)

In Vitro:?DMSO : 100 mg/mL (214.79 mM)

CC(C)(C)Oc1ccc(OCC2Cc3ccccc3CN2C(=O)c2cccc3ccccc23)cc1

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(-20℃)

With Ice Pack

≥ 2 years