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SR-318

CAS No. 2413286-32-3

SR-318( —— )

Catalog No. M26463 CAS No. 2413286-32-3

SR-318 potently inhibits the TNF-α release in whole blood (IC50 = 283 nM). SR-318 is a potent and highly selective inhibitor of p38 MAPK. The IC50 values are 5 nM, 32 nM and 6.11 μM for p38α, p38β and p38α/β, respectively.

Purity : >98% (HPLC)

COA Datasheet HNMR HPLC MSDS Handing Instructions
Size Price / USD Stock Quantity
1 mL x 10 mM in DMSO 50 In Stock
2MG 30 In Stock
5MG 50 In Stock
10MG 84 In Stock
25MG 169 In Stock
50MG 267 In Stock
100MG 384 In Stock
200MG 551 In Stock
500MG Get Quote In Stock
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Biological Information

  • Product Name
    SR-318
  • Note
    Research use only, not for human use.
  • Brief Description
    SR-318 potently inhibits the TNF-α release in whole blood (IC50 = 283 nM). SR-318 is a potent and highly selective inhibitor of p38 MAPK. The IC50 values are 5 nM, 32 nM and 6.11 μM for p38α, p38β and p38α/β, respectively.
  • Description
    SR-318 potently inhibits the TNF-α release in whole blood (IC50 = 283 nM). SR-318 is a potent and highly selective inhibitor of p38 MAPK. The IC50 values are 5 nM, 32 nM and 6.11 μM for p38α, p38β and p38α/β, respectively.(In Vitro):SR-318 shows anti-cancer and anti-inflammatory activity. SR-318 can be used as a chemical probe for targeting this particular inactive state of these two p38 isoforms, p38α/β.
  • In Vitro
    SR-318 presents a potent and selective type-II inhibitor of p38α/β that can be used as a chemical probe for targeting this particular inactive state of these two p38 isoforms.
  • In Vivo
    ——
  • Synonyms
    ——
  • Pathway
    MAPK/ERK Signaling
  • Target
    p38 MAPK
  • Recptor
    ——
  • Research Area
    ——
  • Indication
    ——

Chemical Information

  • CAS Number
    2413286-32-3
  • Formula Weight
    459.58
  • Molecular Formula
    C27H33N5O2
  • Purity
    >98% (HPLC)
  • Solubility
    In Vitro:?DMSO : 125 mg/mL (271.99 mM)
  • SMILES
    Nc(n(-c1ccccc1)nc1)c1C(NCc(cc1)ccc1C(NCCCC1CCCCC1)=O)=O
  • Chemical Name
    ——

Shipping & Storage Information

  • Storage
    (-20℃)
  • Shipping
    With Ice Pack
  • Stability
    ≥ 2 years

Reference

1.Roux FA, Deschamps JY. Inadvertent intrathecal administration of ionic contrast medium to a dog. Vet Radiol Ultrasound. 2007 Sep-Oct;48(5):414-7. Review.
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