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PF-06952229

CAS No. 1801333-55-0

PF-06952229( PF06952229 )

Catalog No. M26371 CAS No. 1801333-55-0

PF-06952229 is an selective and orally active inhibitor of TGFbR1.

Purity : >98% (HPLC)

COA Datasheet HNMR HPLC MSDS Handing Instructions
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Biological Information

  • Product Name
    PF-06952229
  • Note
    Research use only, not for human use.
  • Brief Description
    PF-06952229 is an selective and orally active inhibitor of TGFbR1.
  • Description
    PF-06952229 is an selective and orally active inhibitor of TGFbR1.(In Vivo):In MCF-7 ER+ HER2-xenograft breast cancer tumor model, PF-06952229 (30 mg/kg; gavage) combines with Palbociclib results in an improved inhibition of pSMAD2 and a significant increase in survival.
  • In Vitro
    ——
  • In Vivo
    PF-06952229 (oral gavage; 30 mg/kg; twice daily; 21 days) combines with Palbociclib 21 days results in an improved inhibition of pSMAD2 in the MCF7 ER+?xenograft breast cancer tumor model. This combination also leads to a significant increase in survival relative to PF-06952229 monotherapy. Animal Model:MCF-7 ER+?HER2-xenograft breast cancer tumor modelDosage:30 mg/kg Administration:Oral gavage; twice daily; 44 days Result:Resulted in an increase in tumor growth inhibition when combined with Palbociclib.
  • Synonyms
    PF06952229
  • Pathway
    Others
  • Target
    Other Targets
  • Recptor
    MRP4| OAT1| OAT3
  • Research Area
    ——
  • Indication
    ——

Chemical Information

  • CAS Number
    1801333-55-0
  • Formula Weight
    458.92
  • Molecular Formula
    C23H24ClFN4O3
  • Purity
    >98% (HPLC)
  • Solubility
    In Vitro:?DMSO : 50 mg/mL (108.95 mM)
  • SMILES
    CC(C)c1cnc(cc1Nc1ccncc1C(=O)NC(CO)CO)-c1cc(Cl)ccc1F
  • Chemical Name
    ——

Shipping & Storage Information

  • Storage
    (-20℃)
  • Shipping
    With Ice Pack
  • Stability
    ≥ 2 years

Reference

1.Kamiński T, Micha?owska M, Pawlak D. Aryl hydrocarbon receptor (AhR) and its endogenous agonist - indoxyl sulfate in chronic kidney disease. Postepy Hig Med Dosw (Online). 2017 Jul 30;71(0):624-632. Review.
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