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AZD5904
CAS No. 618913-30-7
AZD5904( AZD 5904 | AZD-5904 )
Catalog No. M15342 CAS No. 618913-30-7
AZD5904 (AZD-5904) is a potent, selective irreversible, orally bioavailable myeloperoxidase (MPO) inhibitor with IC50 of 140 nM.
Purity : >98% (HPLC)
COA
Datasheet
HNMR
HPLC
MSDS
Handing Instructions
| Size | Price / USD | Stock | Quantity |
| 1 mL x 10 mM in DMSO | 69 | In Stock |
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| 5MG | 63 | In Stock |
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| 10MG | 117 | In Stock |
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| 25MG | 275 | In Stock |
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| 50MG | 477 | In Stock |
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| 100MG | 732 | In Stock |
|
| 200MG | Get Quote | In Stock |
|
| 500MG | Get Quote | In Stock |
|
| 1G | Get Quote | In Stock |
|
Biological Information
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Product NameAZD5904
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NoteResearch use only, not for human use.
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Brief DescriptionAZD5904 (AZD-5904) is a potent, selective irreversible, orally bioavailable myeloperoxidase (MPO) inhibitor with IC50 of 140 nM.
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DescriptionAZD5904 (AZD-5904) is a potent, selective irreversible, orally bioavailable myeloperoxidase (MPO) inhibitor with IC50 of 140 nM, similar potency in mouse and rat; displays 10 to 19-fold selective compared to the closely related lactoperoxidase and thyroid peroxidase, >70-fold to a broad panel of other enzymes, ion channels, and receptors; 1 μM AZD5904 inhibited PMA stimulated HOCl by >90% in isolated human neutrophils; a plasma concentration of ~5 μM decreased the in vivo formation of glutathione sulphonamide in rats.Multiple Sclerosis Phase 1 Discontinued.
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In Vitro——
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In Vivo——
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SynonymsAZD 5904 | AZD-5904
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PathwayOthers
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TargetOther Targets
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RecptorOther Targets
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Research AreaInflammation/Immunology
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IndicationMultiple Sclerosis
Chemical Information
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CAS Number618913-30-7
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Formula Weight252.292
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Molecular FormulaC10H12N4O2S
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Purity>98% (HPLC)
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SolubilityDMSO : 125 mg/mL 495.46 mM
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SMILESO=C1NC(N(C[C@H]2OCCC2)C3=C1NC=N3)=S
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Chemical Name6H-Purin-6-one, 1,2,3,7-tetrahydro-3-[[(2R)-tetrahydro-2-furanyl]methyl]-2-thioxo- (9CI)
Shipping & Storage Information
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Storage(-20℃)
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ShippingWith Ice Pack
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Stability≥ 2 years
Reference
molnova catalog
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