M2N12

CAS No. 2376577-06-7

M2N12( —— )

Catalog No. M26288 CAS No. 2376577-06-7

M2N12 is a potent and highly selective inhibitor of cell division cycle 25C protein phosphatase (Cdc25C, IC50 = 0.09 μM). M2N12 has anti-tumor activity.

Purity : >98% (HPLC)

COA Datasheet HNMR HPLC MSDS Handing Instructions
Size Price / USD Stock Quantity
1 mL x 10 mM in DMSO 170 In Stock
5MG 155 In Stock
10MG 250 In Stock
25MG 471 In Stock
50MG 693 In Stock
100MG 1014 In Stock
200MG Get Quote In Stock
500MG Get Quote In Stock
1G Get Quote In Stock

Biological Information

  • Product Name
    M2N12
  • Note
    Research use only, not for human use.
  • Brief Description
    M2N12 is a potent and highly selective inhibitor of cell division cycle 25C protein phosphatase (Cdc25C, IC50 = 0.09 μM). M2N12 has anti-tumor activity.
  • Description
    M2N12 is a potent and highly selective inhibitor of cell division cycle 25C protein phosphatase (Cdc25C, IC50 = 0.09 μM). M2N12 has anti-tumor activity. M2N12 also has promising activity against Cdc25A(IC50 = 0.53 μM) and Cdc25B(IC50 = 1.39 μM).(In Vitro):M2N12 has cytotoxic activity against five tumor cell lines and a normal cell line including A-549(IC50 = 3.92 μM), MDA-MB-231(IC50 = 4.63 μM), KB(IC50 = 5.05 μM), KB-VIN(IC50 = 6.81 μM), MCF-7(IC50 = 4.71 μM) and HBE(IC50 = 6.00 μM).
  • In Vitro
    M2N12 (0-20 μM; 72 hours) has cytotoxic activity against five tumor cell lines and a normal cell line including A-549, MDA-MB-231, KB, KB-VIN, MCF-7 and HBE (IC50=3.92 μM, 4.63 μM, 5.05 μM, 6.81 μM, 4.71 μM and 6.00 μM, respectively).
  • In Vivo
    ——
  • Synonyms
    ——
  • Pathway
    Metabolic Enzyme/Protease
  • Target
    Phosphatase
  • Recptor
    ——
  • Research Area
    ——
  • Indication
    ——

Chemical Information

  • CAS Number
    2376577-06-7
  • Formula Weight
    393.83
  • Molecular Formula
    C20H16ClN5O2
  • Purity
    >98% (HPLC)
  • Solubility
    In Vitro:?DMSO : 11.11 mg/mL (28.21 mM)
  • SMILES
    Cc1ccc(Cn2cc(CNC3=C(Cl)C(=O)c4cccnc4C3=O)nn2)cc1
  • Chemical Name
    ——

Shipping & Storage Information

  • Storage
    (-20℃)
  • Shipping
    With Ice Pack
  • Stability
    ≥ 2 years

Reference

1.Davies FK, Work VH, Beliaev AS, Posewitz MC. Engineering Limonene and Bisabolene Production in Wild Type and a Glycogen-Deficient Mutant of Synechococcus sp. PCC 7002. Front Bioeng Biotechnol. 2014 Jun 19;2:21.
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