Cart
sales@molnova.com
hDHODH-IN-7
CAS No. 1644156-41-1
hDHODH-IN-7( —— )
Catalog No. M26162 CAS No. 1644156-41-1
DHODH-IN-9 (Compound 10k) is a nitrogen-containing analog and is a human dihydrorotatory dehydrogenase inhibitor.
Purity : >98% (HPLC)
COA
Datasheet
HNMR
HPLC
MSDS
Handing Instructions
| Size | Price / USD | Stock | Quantity |
| 1 mL x 10 mM in DMSO | 266 | In Stock |
|
| 2MG | 166 | In Stock |
|
| 5MG | 256 | In Stock |
|
| 10MG | 375 | In Stock |
|
| 25MG | 562 | In Stock |
|
| 50MG | 776 | In Stock |
|
| 100MG | 1042 | In Stock |
|
| 200MG | Get Quote | In Stock |
|
| 500MG | 2102 | In Stock |
|
| 1G | Get Quote | In Stock |
|
Biological Information
-
Product NamehDHODH-IN-7
-
NoteResearch use only, not for human use.
-
Brief DescriptionDHODH-IN-9 (Compound 10k) is a nitrogen-containing analog and is a human dihydrorotatory dehydrogenase inhibitor.
-
DescriptionDHODH-IN-9 (Compound 10k) is a nitrogen-containing analog and is a human dihydrorotatory dehydrogenase inhibitor. DHODH-IN-9 and pMIC50 of 7.4 have antiviral effects.(In Vitro):hDHODH-IN-7 is the corresponding pyridazine homologue from 3-chloro-6-cyclopropylpyridazine. There is almost no change, and the antiviral mode of action of the analogs with 5-cyclopyridine reflects the antiviral effect of homologues with 5-ethylpyrimidinyl groups to some extent. hDHODH-IN-7 is a good antiviral agent for such analogs.
-
In VitroDHODH-IN-9 (Compound 10k) is a corresponding pyridazine homologue from 3-chloro-6-cyclopropylpyridazine. With few variations, the pattern of antiviral effect for analogues featuring a 5-cyclopylpyridine is somehow mirroring the one seen for the 5-ethylpyrimidyl bearing homologues. DHODH-IN-9 (Compound 10k) is a good antiviral of this group of analogue.
-
In Vivo——
-
Synonyms——
-
PathwayMetabolic Enzyme/Protease
-
TargetDehydrogenase
-
RecptorApoptosis
-
Research Area——
-
Indication——
Chemical Information
-
CAS Number1644156-41-1
-
Formula Weight366.44
-
Molecular FormulaC21H23FN4O
-
Purity>98% (HPLC)
-
Solubility——
-
SMILESCC(C)Oc1nn(c(C)c1Cc1ccccc1F)-c1ncc(cn1)C1CC1
-
Chemical Name——
Shipping & Storage Information
-
Storage(-20℃)
-
ShippingWith Ice Pack
-
Stability≥ 2 years
Reference
-
IDH889
IDH889 is a brain penetrant, an allosteric and mutant specific IDH1 inhibitor. IDH889 has effective selectivity for IDH1 R132* mutations (IC50s: 0.02 μM, 0.072 μM, and 1.38 μM for IDH1R132H, IDH1R132C, and IDH1wt).
-
IDH2R140Q-IN-2
IDH2R140Q-IN-2 is an orally active and potent IDH2R140Q inhibitor with an IC50 of 29 nM.IDH2R140Q-IN-2 possesses potential antitumour activity, reducing D2HG production in TF-1 cell lines carrying the IDH2R140Q mutation (IC50 of 10 nM) and inhibiting tumour tissue D2HG levels.
-
CBR-5884
CBR-5884 is an ?selective, active of phosphoglycerate dehydrogenase (PHGDH) inhibitor with an IC50 of 33 μM.?CBR-5884 inhibits de novo serine synthesis in cancer cells and is selectively toxic to cancer cell lines with high serine biosynthetic activity.?
