hDHODH-IN-7

Research use only, not for human use.

DHODH-IN-9 (Compound 10k) is a nitrogen-containing analog and is a human dihydrorotatory dehydrogenase inhibitor.

DHODH-IN-9 (Compound 10k) is a nitrogen-containing analog and is a human dihydrorotatory dehydrogenase inhibitor. DHODH-IN-9 and pMIC50 of 7.4 have antiviral effects.(In Vitro):hDHODH-IN-7 is the corresponding pyridazine homologue from 3-chloro-6-cyclopropylpyridazine. There is almost no change, and the antiviral mode of action of the analogs with 5-cyclopyridine reflects the antiviral effect of homologues with 5-ethylpyrimidinyl groups to some extent. hDHODH-IN-7 is a good antiviral agent for such analogs.

DHODH-IN-9 (Compound 10k) is a corresponding pyridazine homologue from 3-chloro-6-cyclopropylpyridazine. With few variations, the pattern of antiviral effect for analogues featuring a 5-cyclopylpyridine is somehow mirroring the one seen for the 5-ethylpyrimidyl bearing homologues. DHODH-IN-9 (Compound 10k) is a good antiviral of this group of analogue.

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Metabolic Enzyme/Protease

Dehydrogenase

Apoptosis

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1644156-41-1

366.44

C21H23FN4O

>98% (HPLC)

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CC(C)Oc1nn(c(C)c1Cc1ccccc1F)-c1ncc(cn1)C1CC1

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(-20℃)

With Ice Pack

≥ 2 years