Teriflunomide( A77 1726 | HMR 1726 | teriflunomide | Brande name: Aubagio. )

Catalog No. M10335 CAS No. 108605-62-5

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HPLC

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Product Name

Teriflunomide
Note

Research use only, not for human use.
Brief Description

Teriflunomide is the active metabolite of leflunomide, and it acts as an immunomodulatory agent by inhibiting pyrimidine synthesis.
Description

Teriflunomide is the active metabolite of leflunomide, and it acts as an immunomodulatory agent by inhibiting pyrimidine synthesis. It is marketed under the name Aubagio and is indicated for the treatment of multiple sclerosis, specifically relapsing forms.
In Vitro

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In Vivo

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Synonyms

A77 1726 | HMR 1726 | teriflunomide | Brande name: Aubagio.
Pathway

Metabolic Enzyme/Protease
Target

Dehydrogenase
Recptor

Dihydroorotate Dehydrogenase
Research Area

Inflammation/Immunology
Indication

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CAS Number

108605-62-5
Formula Weight

270.21
Molecular Formula

C12H9F3N2O2
Purity

>98% (HPLC)
Solubility

Ethanol: 1 mg/mL ,1; Water: <1 mg/mL (<1 mM); DMSO: 32 mg/mL (118.42 mM)
SMILES

C/C(O)=C(C#N)/C(NC1=CC=C(C(F)(F)F)C=C1)=O
Chemical Name

(Z)-2-cyano-3-hydroxy-N-(4-(trifluoromethyl)phenyl)but-2-enamide.

1.Palmer AM. Curr Opin Investig Drugs. 2010 Nov;11(11):1313-23.

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