Cart
sales@molnova.com
Home - Products - Metabolic Enzyme/Protease - Dehydrogenase - DHODH-IN-13

DHODH-IN-13

CAS No. 1364791-86-5

DHODH-IN-13( —— )

Catalog No. M26154 CAS No. 1364791-86-5

DHODH-IN-13 is the hydroxyfuran analogue of A771726.

Purity : >98% (HPLC)

COA Datasheet HNMR HPLC MSDS Handing Instructions
Size Price / USD Stock Quantity
2MG 264 Get Quote
5MG 404 Get Quote
10MG 593 Get Quote
25MG 888 Get Quote
100MG Get Quote Get Quote
200MG Get Quote Get Quote
500MG Get Quote Get Quote
1G Get Quote Get Quote
Get Quotation Bulk Inquiry Add to Cart

Biological Information

  • Product Name
    DHODH-IN-13
  • Note
    Research use only, not for human use.
  • Brief Description
    DHODH-IN-13 is the hydroxyfuran analogue of A771726.
  • Description
    DHODH-IN-13 is the hydroxyfuran analogue of A771726. DHODH-IN-13 is a dihydroorotate dehydrogenase (DHODH) inhibitor with an IC50 of 4.3 μM for rat liver DHODH. DHODH-IN-13 can be used for rheumatoid arthritis.
  • In Vitro
    DHODH-IN-13 (Compound 7a) is a hydroxyfurazan analog of A771726 and is stable under physiological conditions. When DHODH-IN-13 is docked in silico at the DHODH active site, a BQN-like pose is obtained with the deprotonated furazan hydroxyl facing Arg136 instead of Tyr356, thus effectively mimicking the carboxyl group of BQN and related compounds.
  • In Vivo
    ——
  • Synonyms
    ——
  • Pathway
    Metabolic Enzyme/Protease
  • Target
    Dehydrogenase
  • Recptor
    E3 Ligase Ligand-Linker Conjugate
  • Research Area
    ——
  • Indication
    ——

Chemical Information

  • CAS Number
    1364791-86-5
  • Formula Weight
    273.171
  • Molecular Formula
    C10H6F3N3O3
  • Purity
    >98% (HPLC)
  • Solubility
    ——
  • SMILES
    FC(F)(F)c1ccc(NC(=O)c2no[nH]c2=O)cc1
  • Chemical Name
    ——

Shipping & Storage Information

  • Storage
    (-20℃)
  • Shipping
    With Ice Pack
  • Stability
    ≥ 2 years

Reference

1.Sato T, et al. Cereblon-Based Small-Molecule Compounds to Control Neural Stem Cell Proliferation in Regenerative Medicine. Front Cell Dev Biol. 2021;9:629326. Published 2021 Mar 11.
Calculator

Molecular Weight Calculator

Dilution Calculator

Molarity Calculator

molnova catalog
related products

  • CHIKV-IN-2

    CHIKV-IN-2 shows inhibitory activity against a cellular target Dihydroorotate Dehydrogenase (DHODH), which interacts with various viruses and regulate their replication via depleting intracellular pyrimidine pools.

  • BI?3231

    BI?3231 is a selective and potent inhibitor of hydroxysteroid 17?-dehydrogenase 13 HSD17B13, inhibiting hHSD17B13 and mHSD17B13.BI-3231 can be used for the study of alcohol-associated liver injury, fibrosis and cirrhosis.

  • hDHODH-IN-5

    hDHODH-IN-5 is an inhibitor of human dihydroorotate dehydrogenase.

Sign In Join Free