Ca2+ channel agonist 1( —— )

Catalog No. M26083 CAS No. 1402821-24-2

Ca2+ channel agonist 1 is an agonist of N-type Ca2+ channel and an inhibitor of Cdk2 (EC50s: 14.23 μM and 3.34 μM) and is used as a potential treatment for motor nerve terminal dysfunction.

Purity : >98% (HPLC)

COA

Datasheet

HNMR

HPLC

MSDS

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Biological Information

Product Name

Ca2+ channel agonist 1
Note

Research use only, not for human use.
Brief Description

Ca2+ channel agonist 1 is an agonist of N-type Ca2+ channel and an inhibitor of Cdk2 (EC50s: 14.23 μM and 3.34 μM) and is used as a potential treatment for motor nerve terminal dysfunction.
Description

Ca2+ channel agonist 1 is an agonist of N-type Ca2+ channel and an inhibitor of Cdk2 (EC50s: 14.23 μM and 3.34 μM) and is used as a potential treatment for motor nerve terminal dysfunction.(In Vitro):Ca2+ channel agonist 1 (Compound 13d) exhibits a ca. 2-fold increased agonism and a 22-fold decreased cdk2 kinase activity versus the standard, (R)-roscovitine.
In Vitro

Ca2+ channel agonist 1 (Compound 13d) is an agonist of N-type Ca2+ channel and an inhibitor of Cdk2, with EC50s of 14.23 μM and 3.34 μM, respectively. Ca2+ channel agonist 1 exhibits a ca. 2-fold increased agonism and a 22-fold decreased cdk2 kinase activity versus the standard, (R)-roscovitine.
In Vivo

——
Synonyms

——
Pathway

GPCR/G Protein
Target

Calcium Channel
Recptor

Apoptosis| NF-κB
Research Area

——
Indication

——

Chemical Information

CAS Number

1402821-24-2
Formula Weight

354.458
Molecular Formula

C19H26N6O
Purity

>98% (HPLC)
Solubility

In Vitro:?DMSO : 50 mg/mL (141.06 mM)
SMILES

CCCn1cnc2c(NCc3ccccc3)nc(N[C@H](CC)CO)nc12
Chemical Name

——

Shipping & Storage Information

Storage

(-20℃)
Shipping

With Ice Pack
Stability

≥ 2 years

Reference

1.Cho K, et al. Inhibition of TNF-α-Mediated NF-κB Transcriptional Activity by Dammarane-Type Ginsenosidesfrom Steamed Flower Buds of Panax ginseng in HepG2 and SK-Hep1 Cells. Biomol Ther (Seoul). 2014 Jan;22(1):55-61.

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