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Teriparatide acetate

CAS No. 99294-94-7

Teriparatide acetate( Parathar acetate | hPTH 1-34 (acetate salt) | Forteo )

Catalog No. M25029 CAS No. 99294-94-7

Teriparatide (Human parathyroid hormone-(1-34)) is a PHT agonist, with an IC50 of 2 nM in HEK293 cells.Teriparatide is a recombinant form of parathyroid hormone.

Purity : >98% (HPLC)

COA Datasheet HNMR HPLC MSDS Handing Instructions
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Biological Information

  • Product Name
    Teriparatide acetate
  • Note
    Research use only, not for human use.
  • Brief Description
    Teriparatide (Human parathyroid hormone-(1-34)) is a PHT agonist, with an IC50 of 2 nM in HEK293 cells.Teriparatide is a recombinant form of parathyroid hormone.
  • Description
    Teriparatide (Human parathyroid hormone-(1-34)) is a PHT agonist, with an IC50 of 2 nM in HEK293 cells.Teriparatide is a recombinant form of parathyroid hormone. It is an effective anabolic (i.e., bone growing) agent used to treat some forms of osteoporosis. Intermittent use of Teriparatide activates osteoblasts more than osteoclasts, which leads to an overall increase in bone.(In Vivo):Teriparatide acetate hydrate (Human parathyroid hormone-(1-34) acetate hydrate) (20 μg/kg, i.h.; daily, for 4 weeks; female New Zealand white rabbits) increases the cortical thickness and porosity.
  • In Vitro
    ——
  • In Vivo
    Teriparatide acetate hydrate (Human parathyroid hormone-(1-34) acetate hydrate) (20 μg/kg, i.h.; daily, for 4 weeks; female New Zealand white rabbits) increases the cortical thickness and porosity. Animal Model:Female New Zealand white rabbits Dosage:20 μg/kg Administration:Subcutaneous injection; daily, for 4 weeksResult:Increased the pore ratio, number, and density as well as the cortical area, thickness, and bone mineral content (BMC), without significant influencing the volumetric bone mineral density (BMD).
  • Synonyms
    Parathar acetate | hPTH 1-34 (acetate salt) | Forteo
  • Pathway
    Others
  • Target
    Other Targets
  • Recptor
    PHT
  • Research Area
    ——
  • Indication
    ——

Chemical Information

  • CAS Number
    99294-94-7
  • Formula Weight
    4177.83
  • Molecular Formula
    C183H295N55O53S2
  • Purity
    >98% (HPLC)
  • Solubility
    DMSO:Soluble; Water:Insoluble
  • SMILES
    CC[C@H](C)[C@@H](C(=O)N[C@@H](CCC(=O)N)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CCSC)C(=O)N[C@@H](CC1=CNC=N1)C(=O)N[C@@H](CC(=O)N)C(=O)N[C@@H](CC(C)C)C(=O)NCC(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CC2=CNC=N2)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CC(=O)N)C(=O)N[C@@H](CO)C(=O)N[C@@H](CCSC)C(=O)N[C@@H](CCC(=O)O)C(=O)N[C@@H](CCCNC(=N)N)C(=O)N[C@@H](C(C)C)C(=O)N[C@@H](CCC(=O)O)C(=O)N[C@@H](CC3=CNC4=CC=CC=C43)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CCCNC(=N)N)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CCC(=O)N)C(=O)N[C@@H](CC(=O)O)C(=O)N[C@@H](C(C)C)C(=O)N[C@@H](CC5=CNC=N5)C(=O)N[C@@H](CC(=O)N)C(=O)N[C@@H](CC6=CC=CC=C6)C(=O)O)NC(=O)[C@H](CCC(=O)O)NC(=O)[C@H](CO)NC(=O)[C@H](C(C)C)NC(=O)[C@H](CO)N.CC(=O)O
  • Chemical Name
    ——

Shipping & Storage Information

  • Storage
    (-20℃)
  • Shipping
    With Ice Pack
  • Stability
    ≥ 2 years

Reference

1.Lindsay R, Krege JH, Marin F, Jin L, Stepan JJ. Teriparatide for osteoporosis: importance of the full course. Osteoporos Int. 2016 Feb 22. [Epub ahead of print] Review. PubMed PMID: 26902094.
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