Cart
sales@molnova.com
Rotigotine (b)
CAS No. 92206-54-7
Rotigotine (b)( 1-Naphthalenol, 5,6,7,8-tetrahydro-6-[propyl[2-(2-thienyl)ethyl]amino]- )
Catalog No. M24970 CAS No. 92206-54-7
Rotigotine is an antiparkinson agent and dopamine receptor agonist.
Purity : >98% (HPLC)
COA
Datasheet
HNMR
HPLC
MSDS
Handing Instructions
| Size | Price / USD | Stock | Quantity |
| 1 mL x 10 mM in DMSO | 29 | In Stock |
|
| 10MG | 36 | In Stock |
|
| 25MG | 60 | In Stock |
|
| 50MG | 85 | In Stock |
|
| 100MG | 127 | In Stock |
|
| 200MG | Get Quote | In Stock |
|
| 500MG | Get Quote | In Stock |
|
| 1G | Get Quote | In Stock |
|
Biological Information
-
Product NameRotigotine (b)
-
NoteResearch use only, not for human use.
-
Brief DescriptionRotigotine is an antiparkinson agent and dopamine receptor agonist.
-
DescriptionRotigotine is an antiparkinson agent and dopamine receptor agonist.
-
In VitroRotigotine has a 10-fold selectivity for D3 (pKi=9.2) receptors compared with D2, D4 and D5 (pKi=8.5-8.0) and a 100-fold selectivity compared with D1 receptors (pKi=7.2). In functional studies, Rotigotine behaves as full agonist at all dopamine receptors but notably the potency for stimulation of D1 receptors is similar to that for D2 and D3 receptors (pEC50?respectively: 9.0, 9.4-8.6, 9.7).Rotigotine (10 μM) decreases the number of THir neurons by 40% in primary mesencephalic cell culture. Rotigotine (0.01 μM) slightly protects dopaminergic neurons against MPP+toxicity, significantly protects dopaminergic neurons against rotenone-induced cell death, and significantly inhibits ROS production by rotenone.
-
In Vivo——
-
Synonyms1-Naphthalenol, 5,6,7,8-tetrahydro-6-[propyl[2-(2-thienyl)ethyl]amino]-
-
PathwayGPCR/G Protein
-
TargetDopamine Receptor
-
RecptorDopamine
-
Research Area——
-
Indication——
Chemical Information
-
CAS Number92206-54-7
-
Formula Weight315.47
-
Molecular FormulaC19H25NOS
-
Purity>98% (HPLC)
-
Solubility——
-
SMILESCCCN(CCc1cccs1)C(CC1)Cc2c1c(O)ccc2
-
Chemical Name——
Shipping & Storage Information
-
Storage(-20℃)
-
ShippingWith Ice Pack
-
Stability≥ 2 years
Reference
1.Chen F , Jin L , Nie Z . Safety and Efficacy of Rotigotine for Treating Parkinson's Disease: A Meta-Analysis of Randomised Controlled Trials[J]. Journal of Pharmacy & Pharmaceutical Sciences, 2017, 20:285-.
molnova catalog
related products
-
Aplindore Fumarate
Aplindore Fumarate (DAB-452) is a small molecule dopamine D2 receptor partial agonist.Aplindore Fumarate exhibits high affinity for dopamine D2 and D3 receptors, and low affinity for dopamine D4, 5-hydroxytryptophan (5-HT2), and α1-adrenergic receptors.
-
JNJ-37822681 dihydro...
JNJ-37822681 dihydrochloride is a novel, highly selective dopamine D? receptor antagonist characterized by a rapid dissociation rate from the dopamine D? receptor.
-
Perphenazine dihydro...
Perphenazine dihydrochloride is an orally active dopamine receptor and histamine-1 receptor antagonist that acts on D2 (Ki: 0.56 nM), D3 (Ki: 0.43 nM), and 5-HT2A (Ki: 0.6 nM) receptors, and also binds Alpha-1A adrenergic receptors.
