Cart
sales@molnova.com
A-381393
CAS No. 726174-00-1
A-381393( —— )
Catalog No. M20141 CAS No. 726174-00-1
A-381393 is a selective and brain penetrate dopamine D4 receptor antagonist (Kis: 1.9/1.5/1.6 nM for human dopamine D4.2/D4.4/D4.7 receptor).
Purity : >98% (HPLC)
COA
Datasheet
HNMR
HPLC
MSDS
Handing Instructions
| Size | Price / USD | Stock | Quantity |
| 1 mL x 10 mM in DMSO | 76 | In Stock |
|
| 5MG | 69 | In Stock |
|
| 10MG | 113 | In Stock |
|
| 25MG | 210 | In Stock |
|
| 50MG | 297 | In Stock |
|
| 100MG | 429 | In Stock |
|
| 200MG | 603 | In Stock |
|
| 500MG | Get Quote | In Stock |
|
| 1G | Get Quote | In Stock |
|
Biological Information
-
Product NameA-381393
-
NoteResearch use only, not for human use.
-
Brief DescriptionA-381393 is a selective and brain penetrate dopamine D4 receptor antagonist (Kis: 1.9/1.5/1.6 nM for human dopamine D4.2/D4.4/D4.7 receptor).
-
DescriptionA-381393 is a selective and brain penetrate dopamine D4 receptor antagonist (Kis: 1.9/1.5/1.6 nM for human dopamine D4.2/D4.4/D4.7 receptor).
-
In VitroA-381393 exhibits weak affinity at 5-HT1A, Sigma 2, Adenoceptor α1A, Adenoceptor α2C, Histamine H1, with Kis of 1365, 8600, 2044, 1912 and 2962 nM, respectively.
-
In Vivo——
-
Synonyms——
-
PathwayGPCR/G Protein
-
TargetDopamine Receptor
-
RecptorD4
-
Research Area——
-
Indication——
Chemical Information
-
CAS Number726174-00-1
-
Formula Weight320.43
-
Molecular FormulaC20H24N4
-
Purity>98% (HPLC)
-
SolubilityDMSO: 50 mg/mL (156.04 mM)
-
SMILESCc1ccc(cc1C)N1CCN(Cc2nc3ccccc3[nH]2)CC1
-
Chemical Name2-[[4-(34-dimethylphenyl)piperazin-1-yl]methyl]-1H-benzimidazole
Shipping & Storage Information
-
Storage(-20℃)
-
ShippingWith Ice Pack
-
Stability≥ 2 years
Reference
1.Nakane M et al. 2-[4-(34-Dimethylphenyl)piperazin-1-ylmethyl]-1H benzoimidazole (A-381393) a selective dopamine D4 receptor antagonist. Neuropharmacology. 2005 Jul;49(1):112-21.
molnova catalog
related products
-
Octodrine hydrochlor...
Octodrine hydrochloride is a central nervous stimulant that increases the uptake of dopamine and noradrenaline.
-
PF-592379
A potent, selective, orally active agonist of dopamine D3 receptor with EC50 of 21 nM; displays >470 and 180-fold functional selectivity over D2 and D4 dopamine receptors, respectively.
-
DOV-216,303 Free Bas...
DOV-216,303 Free Base is an inhibitor of serotonin, norepinephrine, and dopamine reuptake with with IC50s of 14, 20 and 78 nM.
