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A-770041
CAS No. 869748-10-7
A-770041( —— )
Catalog No. M24879 CAS No. 869748-10-7
A-770041 is selective and orally active Src-family Lck inhibitor, and the other Src family kinase involved in T-cell signaling.
Purity : >98% (HPLC)
COA
Datasheet
HNMR
HPLC
MSDS
Handing Instructions
| Size | Price / USD | Stock | Quantity |
| 1 mL x 10 mM in DMSO | 145 | In Stock |
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| 2MG | 64 | In Stock |
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| 5MG | 106 | In Stock |
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| 10MG | 179 | In Stock |
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| 25MG | 406 | In Stock |
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| 50MG | 674 | In Stock |
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| 100MG | 1051 | In Stock |
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| 200MG | 1395 | In Stock |
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| 500MG | Get Quote | In Stock |
|
| 1G | Get Quote | In Stock |
|
Biological Information
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Product NameA-770041
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NoteResearch use only, not for human use.
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Brief DescriptionA-770041 is selective and orally active Src-family Lck inhibitor, and the other Src family kinase involved in T-cell signaling.
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DescriptionA-770041 is selective and orally active Src-family Lck inhibitor, and the other Src family kinase involved in T-cell signaling. A-770041 is a 147 nM inhibitor of Lck (1 mM ATP) and is 300-fold selective against Fyn, IC50 value: 147 nM Target: Lck.
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In VitroA-770041 selective inhibits Lck with an IC50 value of 0.147 μM, and inhibits other Src family kinase Src, Fgr, Fyn with IC50s of 9.1, 14.1 and 44.1 μM, respectively.A-770041 (0-30 μM; 2 h) dose-dependently inhibits anti-CD3 induced IL-2 production with an EC50 value of 80 nM.
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In VivoA-770041 (2.5 mg/kg; i.g. once) inhibits concanavalin A-induced IL-2 in vivo.A-770041 (2.5-20 mg/kg/day; for 14 days) dose-dependently increases the survival rate with doses of 5 and 10 mg/kg/day, and survives 100% of transplanted grafts until 14 days with doses of 10 and 20 mg/kg/day. Animal Model:Male Lewis rats Dosage:2.5 mg/kg Administration:Intragastric administration; 2.5 mg/kg once Result:Showed an inhibition of concanavalin A-induced IL-2 with an in vivo EC50 value of 78 nM.
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Synonyms——
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PathwayTyrosine Kinase
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TargetSrc
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RecptorLck
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Research Area——
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Indication——
Chemical Information
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CAS Number869748-10-7
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Formula Weight621.73
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Molecular FormulaC34H39N9O3
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Purity>98% (HPLC)
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SolubilityDMSO: 100 mg/mL (160.84 mM)
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SMILESCC(N(CC1)CCN1C(CC1)CCC1n(c1ncnc(N)c11)nc1-c(cc1)cc(OC)c1NC(c1cc(cccc2)c2n1C)=O)=O
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Chemical Name——
Shipping & Storage Information
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Storage(-20℃)
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ShippingWith Ice Pack
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Stability≥ 2 years
Reference
1.Stachlewitz RF, et al.A-770041, a novel and selective small-molecule inhibitor of Lck, prevents heart allograft rejection.J Pharmacol Exp Ther. 2005 Oct;315(1):36-41.
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