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eCF506
CAS No. 1914078-41-3
eCF506( —— )
Catalog No. M21978 CAS No. 1914078-41-3
eCF506 is a potent and selective inhibitor of SRC (IC50 < 0.5 nM)eCF506, the first small molecule with subnanomolar IC50 for SRC that requires 3 orders of magnitude greater concentration to inhibit ABL.
Purity : >98% (HPLC)
COA
Datasheet
HNMR
HPLC
MSDS
Handing Instructions
| Size | Price / USD | Stock | Quantity |
| 2MG | 51 | In Stock |
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| 5MG | 77 | In Stock |
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| 10MG | 113 | In Stock |
|
| 25MG | 186 | In Stock |
|
| 50MG | 332 | In Stock |
|
| 100MG | 478 | In Stock |
|
| 200MG | Get Quote | In Stock |
|
| 500MG | Get Quote | In Stock |
|
| 1G | Get Quote | In Stock |
|
Biological Information
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Product NameeCF506
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NoteResearch use only, not for human use.
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Brief DescriptioneCF506 is a potent and selective inhibitor of SRC (IC50 < 0.5 nM)eCF506, the first small molecule with subnanomolar IC50 for SRC that requires 3 orders of magnitude greater concentration to inhibit ABL.
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DescriptioneCF506 is a potent and selective inhibitor of SRC (IC50 < 0.5 nM)eCF506, the first small molecule with subnanomolar IC50 for SRC that requires 3 orders of magnitude greater concentration to inhibit ABL. eCF506 exhibits excellent water solubility, an optimal DMPK profile and oral bioavailability, halts SRC-associated neuromast migration in zebrafish embryos without inducing life-threatening heart defects, and inhibits SRC phosphorylation in tumor xenografts in mice.
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In Vitro——
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In Vivo——
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Synonyms——
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PathwayTyrosine Kinase
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TargetSrc
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RecptorSrc
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Research Area——
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Indication——
Chemical Information
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CAS Number1914078-41-3
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Formula Weight510.63
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Molecular FormulaC26H38N8O3
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Purity>98% (HPLC)
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SolubilityDMSO:62.5 mg/mL (122.40 mM; Need ultrasonic)
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SMILESCOc1cc(ccc1NC(=O)OC(C)(C)C)-c1nn(CCN2CCC(CC2)N(C)C)c2ncnc(N)c12
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Chemical Name——
Shipping & Storage Information
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Storage(-20℃)
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ShippingWith Ice Pack
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Stability≥ 2 years
Reference
1.Fraser C, et al. Rapid Discovery and Structure-Activity Relationships of Pyrazolopyrimidines That Potently Suppress Breast Cancer Cell Growth via SRC Kinase Inhibition with Exceptional Selectivity over ABL Kinase. J Med Chem. 2016 May 26;59(10):4697-710.
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